基于数据挖掘的藏医药治疗真布病用药规律研究  

Medication Rules of Tibetan Medicine in Treating Zhenbu Disease Based on Data Mining

作　　者：格知加 扎西卓玛 李秀优 卓玛措 南兴加 仁增平措 尼玛次仁 Ge Zhijia;Zhaxi Zhuoma;Li Xiuyou;Zhuoma Cuo;Nan Xingjia;Renzeng Pingcuo;Nima Ciren(University of Tibetan Medicine,Lhasa 850000;Jianzha Tibetan Hospital,Jianzha 811299;Qinghai(Tso-Ngon)University Tibetan Medical College,Xining 810000)

机构地区：[1]西藏藏医药大学,拉萨8850000 [2]尖扎县藏医院,尖扎811299 [3]青海大学藏医学院,西宁810000

出　　处：《中药药理与临床》2023年第8期97-102,共6页Pharmacology and Clinics of Chinese Materia Medica

基　　金：中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者项目(2019);青海省中藏医药科研创新项目(编号:J202006);青海省中藏医药(循证)研究课题项目(编号:2019205);中国民族医药学会科研项目(编号:2020MZ009-270005)。

摘　　要：目的:探讨藏医药治疗真布病的组方用药规律,为临床用药及成药研发提供参考。方法:在《四部医典》《藏医临床札记》等藏医古籍中寻找用于治疗真布病的方剂,建立组方数据库,使用R version4.1.1和Excel进行药物频次分析、用量分析、关联规则分析、聚类分析,多角度探析治疗真布病的用药规律与特征。结果:通过数据挖掘分析发现,方剂统计共得二十五味旺查丸、五味宽筋藤等18首高频方剂,单味药统计共得到诃子、白豆蔻、红花等32味单味药;六味三化味药统计发现甘味和苦味最常用,苦化味最常见;高频药物的药用剂量以0.2 g~0.4 g的区间使用最多,但因方剂中的定位不同,导致入药剂量各具特色;关联规则分析中得到15组二项常用药对,其中麝香-诃子,川木香-诃子最常见;6组三项常用药对,其中毛诃子、余甘子-诃子最常见;聚类分析得到7组针对不同证型的常用组方。结论:通过数据挖掘方式,客观总结出藏医药治疗真布病的用药规律。Objective:To explore the medication rules of Tibetan medicine in treating Zhenbu disease and provide references for clinical application and development of Tibetan medicine.Methods:The prescriptions treating Zhenbu disease were collected from the ancient books of Tibetan medicine such as Four Medical Tantras and Clinical Notes of Tibetan Medicine,and the prescription database was established.R version 4.1.1 and Excel were used to analyze the frequency,dosage,association rules,and cluster of the medicine to find the potential medication rules and characteristics of treating Zhenbu disease.Results:Eighteen prescriptions with high-frequency application including twenty-five-ingredient Wangcha pill and five-ingredient Kuanjinteng were found.Thirty-two medicines with single ingredient including Chebulae Fructus,Amomi Fructus Rotundus,and Carthami Flos were found.According to the analysis of six tastes and three tastes after digestion,the most common tastes were the sweet taste,the bitter taste,and the bitter taste after digestion.The dose of medicines frequently used was generally in the range of 0.2 g~0.4 g,but the specific dose was determined by the role of the medicine in the prescription.Fifteen two-medicine compatibilities that frequently used were obtained by association rules.The most common two-medicine compatibilities were Moschus-Chebulae Fructus and Vladimiriae Radix-Chebulae Fructus.Six three-medicine compatibilities were obtained,and the Terminaliae Belliricae Fructus-Phyllanthi Fructus-Chebulae Fructus compatibility was the most common one.Seven commonly-used prescriptions aimed to different syndromes were obtained by cluster analysis.Conclusion:The medication rules of Tibetan medicine in treating Zhenbu disease were objectively summarized through data mining.

关 键 词：真布病 藏医药 数据挖掘 用药规律 

分 类 号：R29[医药卫生—民族医学]