中国人群生命早期经历饥荒暴露与成年后代谢综合征风险的meta分析  

Famine exposure during early life and risk of metabolic syndrome in adulthood in China: a meta-analysis

作　　者：杨琼 张秋 肖英 徐丹青 黎学颖 张迷磊 陈海燕 莫彬彬 戴霞[1] Yang Qiong;Zhang Qiu;Xiao Ying;Xu Danqing;Li Xueying;Zhang Milei;Chen Haiyan;Mo Binbin;Dai Xia(Department of Endocrinology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;The People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院内分泌科,南宁530021 [2]广西壮族自治区人民医院,南宁530021

出　　处：《中华内分泌代谢杂志》2023年第8期659-666,共8页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金项目(82160440)。

摘　　要：目的分析中国人群生命早期饥荒暴露与代谢综合征风险的关系。方法计算机检索CNKI、维普网、万方、CBM、Web of science、PubMed等数据库关于我国人群生命早期饥荒暴露与代谢综合征风险的相关文献,检索时限为建库到2022年10月。由2名研究人员分别对文献数据独立提取和系统评估,采用Stata 16.0软件进行meta分析。结果共12篇文献符合纳入标准,包括71470例研究对象。Meta分析结果显示,生命早期饥荒暴露可增加中国人群发生代谢综合征的风险(OR=1.28,95%CI 1.16~1.40)。亚组分析结果显示,与未暴露组相比,胎儿期饥荒暴露(OR=1.25,95%CI 1.03~1.52)和儿童期饥荒暴露(OR=1.29,95%CI 1.15~1.45)均增加代谢综合征的发病风险,仅在女性人群中发现这种显著相关性。结论生命早期经历饥荒暴露可能会增加中国人群成年后患代谢综合征的风险,这主要表现在女性群体中。Objective To analyze the relationship between early-life famine exposure and the risk of metabolic syndrome in Chinese population.Methods Relevant literature on the relationship between early-life famine exposure and the risk of metabolic syndrome in the Chinese population was retrieved from databases such as CNKI,Wanfang,VIP,CBM,Web of Science,and PubMed.The search was conducted from the inception of the databases up to October 2022.Two researchers independently extracted and systematically evaluated the data from the literature,and meta-analysis was performed using Stata 16.0 software.Results A total of 12 publications met the inclusion criteria,including 71470 study subjects.Meta-analysis results showed that early-life famine exposure increased the risk of metabolic syndrome in the Chinese population(OR=1.28,95%CI 1.16-1.40).Subgroup analysis showed that both fetal famine exposure(OR=1.25,95%CI 1.03-1.52)and childhood famine exposure(OR=1.29,95%CI 1.15-1.45)increased the risk of developing metabolic syndrome compared to the non-exposed group,and this significant association was only found in the female population.Conclusion Early-life exposure to famine may increase the risk of developing metabolic syndrome in adulthood in the Chinese population,particularly among females.

关 键 词：饥荒暴露 代谢综合征 META分析 系统评价 

分 类 号：R589[医药卫生—内分泌]