胰升糖素样肽-1对男性生殖功能的影响  

Effects of glucagon-like peptide-1 on male reproductive function

作　　者：尹德杉 夏利 魏蕊[1] Yin Deshan;Xia Li;Wei Rui(Department of Endocrinology and Metabolism,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院内分泌科,北京100191

出　　处：《中华内分泌代谢杂志》2023年第8期719-721,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：国家重点研发计划"生育健康及妇女儿童健康保障"重点专项 (2022YFC2702600)。

摘　　要：随着糖尿病发病的年轻化,其带来的生殖功能障碍受到广泛关注。高血糖与胰岛素抵抗是引发男性生殖功能障碍的高危因素,肥胖可能加重疾病的发生发展。胰升糖素样肽-1及其受体激动剂通过降低血糖、减轻体重、抑制炎症反应等方式,改善机体整体的健康状态,间接发挥生殖系统的保护作用;可通过影响神经内分泌功能进而改善生殖功能;或直接作用于睾丸的支持细胞、间质细胞等保护生殖功能。然而一些研究并未发现保护作用,尚需高质量的临床研究进一步证实。胰升糖素样肽-1受体激动剂可能是改善糖尿病男性患者生殖功能障碍的治疗选择。With the younger onset of diabetes,the reproductive dysfunction caused by diabetes has received widespread attention.Hyperglycemia and insulin resistance,the main features of diabetes,are high-risk factors for male reproductive dysfunction.Obesity,the common co-morbidity of diabetes,may aggravate the progression of reproductive dysfunction.Glucagon-like peptide-1(GLP-1)and its receptor agonists improve the overall health status by lowering blood glucose,reducing body weight,and inhibiting inflammatory response,which indirectly exerts protective effects on the reproductive system.GLP-1 also protects reproductive function by regulating the neuroendocrine function,and directly acting on the supporting cells and interstitial cells of the testis.However,some studies did not find the protective effects.High-quality clinical studies are needed.GLP-1 receptor agonists may be a therapeutic option to improve reproductive dysfunction in diabetic men.

关 键 词：胰升糖素样肽-1 糖尿病 男性生殖功能 

分 类 号：R587.1[医药卫生—内分泌]