麦角酰二乙胺类物质1-环丙酰基-麦角酰二乙胺(1cP-LSD)的定性检验  

Identifi cation of a Lysergic Acid Diethylamide Analogue 1-Cylopropanoyl-LSD in Seized Material by GC-MS and UPLC-QExactive Orbitrap-MS

作　　者：沈瑞迪 李彭 钱振华[1] SHEN Ruidi;LI Peng;QIAN Zhenhua(Drug Intelligence and Forensic Center of the Ministry of Public Security,Beijing 100193,China)

机构地区：[1]公安部禁毒情报技术中心,北京100193

出　　处：《刑事技术》2023年第5期498-504,共7页Forensic Science and Technology

基　　金：国家重点研发计划国家质量基础设施体系专项课题(2021YFF0602501);中央级公益性科研院所基本科研业务费专项资金项目(2021JB009)。

摘　　要：针对在中国未见报道的麦角酰二乙胺类物质1-环丙酰基-麦角酰二乙胺,建立其气相色谱-质谱(GC-MS)、超高效液相色谱-四极杆/静电场轨道阱高分辨质谱联用(UPLC-Q-Exactive Orbitrap-MS)定性检验方法。本文对未知样品用甲醇和水提取,取上清液,分别采用GC-MS和UPLC-Q-Exactive Orbitrap-MS进行分析,麦角酰二乙胺(lysergic acid diethylamide,LSD)进行同步对照分析。经GC-MS检测,保留时间为23.85 min的未知组分的质谱碎片主要特征离子峰有m/z 221,289,391,69,181,207,249,348。经UPLCQ-Exactive Orbitrap-MS检测,保留时间为3.99 min的未知组分的准分子离子峰为m/z 392.2328,二级质谱主要离子有m/z 291.1487,349.1904,281.1643,265.1333,223.1226,208.0753,251.1176。基于缺少对照品的现状,经SWGDRUG和Cayman谱库检索、已报道文献中信息比对及对其高分辨质谱数据的解析,实现了目标物确认,鉴定为1-环丙酰基-麦角酰二乙胺(1-cylopropanoyl-lysergic acid diethylamide,1cP-LSD)。该方法具有分析简便、快速的特点,有很好的应用前景,可以用于实际案件的检测。Lysergic acid diethylamide(LSD)is the most potent semi-artificial hallucinogenic agent currently known.Recreational LSD use became a central,highly-visible aspect of the 1960s youth counterculture movement,eventually paving the way for international prohibition in 1971.But nowadays,more and more criminals utilize chemical knowledge and advanced technology to modify the structure of controlled drugs and produce new psychoactive substances(NPSs)that are not controlled by law in order to escape legal sanctions.NPSs do great harm to human health.In recent years,several lysergamide derivatives have been distributed as NPSs in the world.In this study,we presented a method for the identifi cation of the lysergic acid diethylamide analogue 1-cylopropanoyl-lysergic acid diethylamide seized for the fi rst time in China by gas chromatography-mass spectrometry(GC-MS)and ultra performance liquid chromatography-electrospray ionization quadrupole/electrostatic fi eld-Orbitrap-mass spectrometry(UPLC-Q-Exactive Orbitrap-MS).Unknown sample was extracted with methanol and water,and the supernatant was taken and analyzed by GC-MS and UPLC-Q-Orbitrap-MS,while lysergic acid diethylamide(LSD)was studied as a contrast.By GC-MS detection,the main characteristic ion peaks of mass spectrometry fragments of unknown components with retention time of 23.85 min were m/z 221,289,391,69,181,207,249,348.By UPLC-Q-Exactive Orbitrap-MS detection,the excimer ion peak of the unknown component with a retention time of 3.99 min is m/z 392.2328,and the main ion of the secondary mass spectrum were m/z 291.1487,349.1904,281.1643,265.1333,223.1226,208.0753,251.1176.Based on the lack of reference substance,the target object was identifi ed as 1-cylopropanoyl-lysergic acid diethylamide(1cP-LSD)after the SWGDRUG spectral library and Cayman spectral library search,the information comparison in the reported literature and the analysis of its high-resolution mass spectrometry data.The method is simple and rapid,and has a good application prospect,which can be us

关 键 词：麦角酰二乙胺类 1-环丙酰基-麦角酰二乙胺 气相色谱–质谱联用(GC-MS) 超高效液相色谱–四极杆/静电场轨道阱高分辨质谱联用(UPLC-Q-Exactive Orbitrap-MS) 

分 类 号：D918.9[政治法律—法学] O657.63[理学—分析化学]