卵母细胞滑面内质网聚集对早期胚胎发育及妊娠结局影响的研究进展  

Research progress on the effect of oocyte smooth endoplasmic reticulum clusters on early embryo development and pregnancy outcome

作　　者：黄晗 易红艳 马燕琳[1,2,3] HUANG Han;YI Hong‑yan;MA Yan‑lin(Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research,Department of Reproductive Medicine,Hainan Provincial Clinical Research Center for Thalassemia,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China;Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University,Haikou 571199,China;Haikou Key Laboratory for Preservation of Human Genetic Resource,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China)

机构地区：[1]海南医学院第一附属医院海南省人类生殖与遗传重点实验室,生殖医学科,海南省地方病(地中海贫血)临床医学研究中心,海南海口570102 [2]海南医学院热带转化医学教育部重点实验室,海南海口571199 [3]海南医学院第一附属医院海口市人类遗传资源保藏重点实验室,海南海口570102

出　　处：《海南医学院学报》2023年第19期1510-1514,共5页Journal of Hainan Medical University

基　　金：国家自然科学基金资助项目(82072880,81960283);海南省科技项目资助(LCYX202102);海南省重大科技计划项目(ZDKJ2017007)。

摘　　要：随着人类辅助生殖技术中卵胞浆内单精子注射(intracytoplasmic sperm injection,ICSI)技术在临床中的发展及其应用,人卵母细胞质量的评估被认为对成功怀孕和植入至关重要。迄今已有许多关于卵母细胞形态影响胚胎发育的报道。既往多项研究中表明卵母细胞内滑面内质网聚集体(smooth endoplasmic reticulum clusters,SERC)的出现可能会影响卵母细胞的受精及胚胎的发育进程。然而,随着近年来含SERC卵母细胞的正常体外受精并获得健康后代的报道逐渐增多,临床上对于是否继续使用含SERC卵母细胞进行辅助生殖治疗仍存在一定争议。基于此,本综述旨在对近年来国内外关于卵母细胞内SERC的研究进展进行综述。With the clinical development and application of intracytoplasmic sperm injection(ICSI)technology in human assisted reproduction,the influence of oocyte quality on embryo development has been paid more and more attention.So far,there have been many reports on oocyte morphology affecting embryo development.It has been found in some works that the appearance of smooth endoplasmic reticulum clusters(SERC)in oocytes may affect the fertilization and embryo development of oocytes.However,with the increasing reports of SERC-containing oocytes obtained by in vitro fertilization and healthy offspring in recent years,there is still some controversy on whether to continue to use SERC-containing oocytes for the following assisted reproduc-tive therapy in clinical practice.Based on this,this review aims to review the research progress of SERC in oocytes in recent years.

关 键 词：滑面内质网聚集体 卵母细胞 妊娠率 流产率 畸形率 

分 类 号：R714.8[医药卫生—妇产科学]