HIF-1α在动脉粥样硬化中的作用研究进展  

Research progress on the role of HIF-1α in atherosclerosis

作　　者：苑明川 王莉[2] 王贺[2] 陈玉善[2] 关怀敏[2] YUAN Mingchuan;WANG Li;WANG He;CHEN Yushan;GUAN Huaimin(Henan University of Chinese Medicine,Zhengzhou,Henan 450099,China;Heart Center of the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,Henan 450000,China)

机构地区：[1]河南中医药大学,河南省郑州市450099 [2]河南中医药大学第一附属医院心脏中心,河南省郑州市450000

出　　处：《中国动脉硬化杂志》2023年第9期815-820,共6页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金面上项目(81473507和81803940);河南省中医管理局重大专项(2019ZYZD04和2019JDZX2010)。

摘　　要：缺氧诱导因子1α(HIF-1α)是细胞对低氧反应的主要调节因子,在动脉粥样硬化(As)斑块的缺氧环境下被诱导高表达。HIF-1α是促进As进展的关键蛋白,广泛参与As的发生和发展过程。文章综述了HIF-1α的结构和功能,以及其在内皮细胞、血管平滑肌细胞、单核巨噬细胞和CD4~+T细胞分化中的作用,旨在为基于HIF-1α的As防治提供新的思路。The hypoxia inducible factor-1α(HIF-1α)is a major regulator of the cellular response to hypoxia,and its high expression is induced in the hypoxic environment of atherosclerosis(As)plaques.It is a key protein to promote the progression of As and widely involved in the occurrence and development of As.This article reviews the structure and function of HIF-1αand its role in endothelial cells,vascular smooth muscle cells,mononuclear macrophages and the differentiation of CD4+T cells,in order to provide new ideas for the prevention and treatment of As based on HIF-1α.

关 键 词：动脉粥样硬化 缺氧诱导因子1Α 内皮细胞 平滑肌细胞 单核巨噬细胞 CD4~+T细胞 

分 类 号：R5[医药卫生—内科学] R363[医药卫生—临床医学]