基于MAPK主要信号通路探讨动物抗菌肽免疫调控机制研究进展  

Research progress on immune regulation mechanism of animalantimicrobial peptides based on MAPK main signaling pathway

作　　者：徐晨露 夏嫱 XU Chenlu;XIA Qiang(Department of Basic Education,Zhuhai Campus of Zunyi Medical University,Zhuhai 519041,China)

机构地区：[1]遵义医科大学珠海校区基础教学部,珠海519041

出　　处：《生物学杂志》2023年第5期94-98,共5页Journal of Biology

基　　金：国家自然科学基金项目(32060127);贵州省科技计划项目(黔科合基础-ZK[2021]一般101)。

摘　　要：重点介绍近年来有关动物抗菌肽基于MAPK信号通路免疫调控机制方面的最新研究进展。概述JNK、P38 MAPK、ERK等3个MAPK亚通路及动物抗菌肽基于MAPK通路免疫调控机制的研究现状,阐明哺乳类、鸟类、爬行类、两栖类、鱼类、昆虫类及甲壳类动物抗菌肽通过磷酸化MAPK通路参与免疫反应的机制。通过对各类动物抗菌肽基于MAPK通路免疫调控机制的整理和总结,期待能够为全面深入研究抗菌肽作用机制及抗菌肽在医药领域作用靶点研究提供参考。The latest research progress of animal antibacterial peptides in immunoregulation mechanisms was mainly introduced based on the MAPK signaling pathway in recent years.The research status of three MAPK subpathways,JNK,P38 MAPK and ERK,and the immunological regulation effects of animal antimicrobial peptides based on the MAPK pathway were summarized.The mechanisms by which antimicrobial peptides from mammals,birds,reptiles,amphibians,fish,insects and crustaceans through phosphorylation of MAPK pathway to involve in immune responses were also elucidated.The immunomodulatory mechanisms of various animal antimicrobial peptides based on the MAPK pathway were arranged and summarized,hoping to provide a literature reference for the comprehensive and in-depth research of the mechanism of antimicrobial peptides and the acting targets of antimicrobial peptides in the field of medicine.

关 键 词：抗菌肽 丝裂原活化蛋白激酶 信号通路 免疫调控 机制 

分 类 号：Q959.9[生物学—动物学] Q516