抗菌肽作为免疫调节剂治疗细菌感染的潜力  

Prospects of Antimicrobial Peptides as Immunomodulators in the Treatment of Bacterial Infections

作　　者：梁国柱 阮诗媚 何艳梅 杨海龙 LIANG Guozhu;RUAN Shimei;HE Yanmei;YANG Hailong(School of Basic Medicine,Kunming Medical University,Kunming Yunnan 650500,China)

机构地区：[1]昆明医科大学基础医学院,云南昆明650500

出　　处：《昆明医科大学学报》2023年第10期189-195,共7页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(82372259);云南省科技厅科技计划基金资助项目(202301AY070001-015)。

摘　　要：自1928年青霉素被用于治疗细菌感染性疾病以来,抗生素拯救了无数患者的生命。然而,随着细菌抗药性的增加,细菌感染性疾病的临床治疗变得愈发困难。抗菌肽因其功能广泛且毒副作用低等特点,被认为是理想的传统抗生素替代品。其中,一些具有免疫调节功能的抗菌肽能够调节机体自身的固有免疫和获得性免疫反应,直接靶向机体免疫系统而非病原微生物,从而避免对病原微生物的选择压力,不易产生耐药性,在抗感染治疗方面具有广阔的应用价值。将从抗菌肽的免疫调节活性、临床治疗中的应用潜力以及局限性等方面进行概述,为新型抗生素的开发利用提供新的视野。Since penicillin was used to treat bacterial infectious diseases in 1928,antibiotics have saved countless patients’lives.However,with the increase of bacterial drug resistance,the clinical treatment of bacterial infectious diseases has become increasingly difficult.Antimicrobial peptides is considered as an ideal substitute for traditional antibiotics because of its wide range of functions and low toxicity.Among them,some antimicrobial peptides with immune regulation function can regulate the innate immunity and acquired immune response of the body,directly target the immune system of the body rather than pathogenic microorganisms,thus avoiding the selection pressure on pathogenic microorganisms,and are not easily resistant to antibiotics.They have broad application value in infection treatment.This article reviews the immunomodulatory activity of antimicrobial peptides,its potential application in clinical treatment,and its limitations,so as to provide a new perspective for the development and utilization of new antibiotics.

关 键 词：细菌感染 抗菌肽 免疫调节 

分 类 号：R392.11[医药卫生—免疫学]