辅助应用右美托咪定及地佐辛对甲状腺手术全凭静脉麻醉患者围术期应激指标及血流动力学指标的影响  

Effects of Dexmedetomidine and Dezocine on Perioperative Stress and He⁃modynamic Indexes in Patients with Intravenous Anesthesia During Thy⁃roid Surgery

作　　者：李陆军 孙振全[1] LI Lujun;SUN Zhenquan(Department of Anesthesiology,Nanjing Hospital of Integrative Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,Jiangsu Province,210014 China)

机构地区：[1]南京中医药大学附属南京市中西医结合医院麻醉科,江苏南京210014

出　　处：《系统医学》2023年第13期58-62,共5页Systems Medicine

摘　　要：目的研究辅助应用右美托咪定以及地佐辛对甲状腺手术全凭静脉麻醉患者围术期应激指标以及血流动力学指标的影响情况。方法选取2019年7月—2020年7月南京中医药大学附属南京市中西医结合医院收治的60例甲状腺手术患者为研究对象,采用随机数表法将其分为研究组与对照组,每组30例,对照组采用地佐辛进行麻醉,研究组采用右美托咪定联合地佐辛进行麻醉,对比两组患者在围术期应激指标、生命体征指标、苏醒时间。结果研究组麻醉后血清谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)水平为(85.65±12.55)U/L、超氧化物歧化酶(superoxide dismutase,SOD)水平为(62.44±3.16)U/mL,均低于对照组,差异有统计学意义(t=2.912、4.710,P<0.05)。研究组麻醉后丙二醛(malondialdehyde,MDA)高于对照组,差异有统计学意义(P<0.001)。麻醉后,研究组心率低于对照组,差异有统计学意义(P<0.05)。研究组自主恢复呼吸以及苏醒时间短于对照组,差异有统计学意义(P<0.05)。结论右美托咪定能够有效降低患者在苏醒期的躁动,且抑制患者的应激反应,将其与地佐辛进行联合应用,能够帮助患者保持更稳定的血流动力学,并改善患者的苏醒质量,值得在临床进行大样本前瞻性研究,进一步证实。Objective To study the effects of dexmedetomidine and dezocine on perioperative stress and hemodynamic indexes in patients with intravenous anesthesia during thyroid surgery.Methods From July 2019 to July 2020,60 pa⁃tients with thyroid surgery admitted to Nanjing Hospital of Integrated Traditional Chinese and Western Medicine Affili⁃ated to Nanjing University of Traditional Chinese Medicine from July 2019 to July 2020 were selected as the research objects.They were divided into study group and control group by random number table method,30 cases in each group.The control group was anesthetized with dezocine,and the study group was anesthetized with dexmedetomidine combined with dezocine.The perioperative stress indexes,vital signs indexes and recovery time of the two groups were compared.Results After anesthesia,the levels of serum glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)in the study group were(85.65±12.55)U/L and(62.44±3.16)U/mL,which were lower than those in the control group,and the differences were statistically significant(t=2.912,4.710,P<0.05).The malondialdehyde(MDA)after an⁃esthesia in the study group was higher than that in the control group,and the difference was statistically significant(P<0.001).After anesthesia,the heart rate of the study group were lower than those of the control group,and the differ⁃ence was statistically significant(P<0.05).The time of spontaneous recovery of respiration and recovery in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Dexmedetomidine can effectively reduce the agitation of patients during the recovery period and inhibit the stress re⁃sponse of patients.Combined application of dexmedetomidine with dezocine can help patients maintain more stable hemodynamics and improve the quality of recovery of patients,which is worthy of large-scale prospective clinical stud⁃ies for further validation.

关 键 词：右美托咪定 地佐辛 甲状腺手术 应激反应 血流动力学 

分 类 号：R4[医药卫生—临床医学]