肝硬化患者凝血4项与D2聚体的检测分析  

Analysis of Four Coagulation Items and D2 Polymers in Patients with Cir⁃ rhosis

作　　者：尹明月 许觉彬 季沈杰 YIN Mingyue;XU Juebin;JI Shenjie(Department of Laboratory,Qidong People's Hospital/Qidong Institute of Liver Cancer Prevention and Treatment/Qidong Hospital Affiliated to Nantong University,Qidong,Jiangsu Province,226200 China)

机构地区：[1]启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院检验科,江苏启东226200

出　　处：《系统医学》2023年第13期63-65,69,共4页Systems Medicine

摘　　要：目的 检测分析肝硬化患者凝血4项与D2聚体(d-dimer, D-D)变化情况。方法 选取2022年1—10月启东市人民医院收治的50例肝硬化患者为研究组,另以同期在本院进行体检的50例健康志愿者为对照组,所有人员均进行凝血4项与D-D检查,比较两组凝血酶时间(thrombin time, TT)、凝血酶原时间(prothrombin time,PT)、活化部分凝血活酶时间(activatedpartialthromboplastintime,APTT)及纤维蛋白原(fibrinogen,FIB)及D-D水平。结果研究组TT、PT、APTT、FIB及D-D水平分别为(22.16±3.02)s、(15.49±2.52)s、(41.83±4.12)s、(2.10±0.54)g/L、(3.35±0.96)mg/L,与对照组的(17.30±2.24)s、(10.68±2.14)s、(28.03±3.65)s、(2.71±0.67)g/L、(0.17±0.05)mg/L比较,差异有统计学意义(t=9.140、10.288、17.728、5.012、21.258,P<0.001)。研究组Child-Pugh A级TT、PT、APTT、D-D短于B级、C级,FIB水平高于B级、C级;Child-Pugh B级TT、PT、APTT、D-D水平均优于C级,FIB水平高于C级,差异有统计学意义(P<0.05)。结论 肝硬化患者凝血4项与D-D水平发生异常改变,且不同肝功能分级患者凝血4项与D-D水平存在明显差异,可为临床诊断肝硬化及评估肝功能损伤提供指导。Objective The changes of coagulation 4 items and d-dimer(D-D)in patients with cirrhosis were detected and analyzed.Methods From January to October 2022,50 patients with liver cirrhosis admitted to Qidong People's Hospital were selected as the study group,and 50 healthy volunteers who underwent physical examination in our hos⁃pital during the same period were selected as the control group.All personnel underwent 4 items of coagulation and D-D examination.The levels of thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)and D-D were compared between the two groups.Results TT,PT,APTT,FIB and D-D in the study group were(22.16±3.02)s,(15.49±2.52)s,(41.83±4.12)s,(2.10±0.54)g/L and(3.35±0.96)mg/L,respectively,which were compared with(17.30±2.24)s,(10.68±2.14)s,(28.03±3.65)s,(2.71±0.67)g/L and(0.17±0.05)mg/L in the con⁃trol group,the difference was statistically significant(t=9.140,10.288,17.728,5.012,21.258,P<0.001).The Child-Pugh A-grade TT,PT,APTT,D-D in the study group were all shorter than those in B-grade and C-grade,while FIB levels was higher than that in B-grade and C-grade;the levels of TT,PT,APTT,and D-D in Child-Pugh B-grade were better than those in C-grade,while the FIB level was higher than that in C-grade,the difference was statistically significant(P<0.05).Conclusion There are abnormal changes in the levels of blood clotting and D-D in patients with cirrhosis,and there are obvious differences in the levels of blood clotting and D-D in patients with different liver func⁃tion grades,which can provide guidance for clinical diagnosis of cirrhosis and evaluation of liver function injury.

关 键 词：肝硬化 D2聚体 凝血4项 

分 类 号：R4[医药卫生—临床医学]