分析环磷酰胺冲击疗法治疗小儿肾病综合征的疗效及对肾功能的影响  

Analysis of the Efficacy of Cyclophosphamide Pulse Therapy in the Treatment of Nephrotic Syndrome in Children and Its Impact on Renal Function

作　　者：朱国琴 张林[1] 赵丽萍[1] ZHU Guoqin;ZHANG Lin;ZHAO Liping(Department of Renal Rheumatology and Immunology,Wuxi Children's Hospital,Wuxi,Jiangsu Province,214000 China)

机构地区：[1]无锡市儿童医院肾脏风湿免疫科,江苏无锡214000

出　　处：《系统医学》2023年第14期66-69,共4页Systems Medicine

摘　　要：目的评估小儿肾病综合征行环磷酰胺冲击治疗的效果。方法选取2018年1月—2022年11月无锡市儿童医院收治的82例小儿肾病综合征患儿为研究对象,采用单双数分为两组,每组41例。一般组方案为甲泼尼龙治疗,治疗组方案为环磷酰胺冲击治疗。比较两组肾功能、肝功能指标、缓解率、不良反应发生率。结果治疗后,治疗组24 h尿蛋白定量、血肌酐水平均低于一般组,差异有统计学意义(P<0.05)。治疗后,治疗组白蛋白、总蛋白水平均高于一般组,差异有统计学意义(P<0.05)。治疗组缓解率为97.56%,高于一般组,差异有统计学意义(χ^(2)=4.986,P<0.05)。治疗组不良反应发生率为4.88%,明显低于一般组,差异有统计学意义(χ^(2)=8.022,P<0.05)。结论环磷酰胺冲击疗法不良反应少,对肾功能有改善作用,还能减轻肝脏损伤,提高小儿肾病综合征缓解率。Objective To evaluate the effect of cyclophosphamide pulse therapy in children with nephrotic syndrome.Methods A total of 82 children with nephrotic syndrome treated in Wuxi Children's Hospital from January 2018 to November 2022 were selected as the study objects,and were divided into two groups by using odd and even numbers,with 41 cases in each group.The general group was methylprednisolone therapy and the treatment group was cyclophosphamide shock therapy.Renal function,liver function indexes,remission rate and incidence of adverse reactions were compared between the two groups.Results After treatment,24 h urinary protein quantity and serum creatinine level in the treatment group were lower than those in the general group,and the differences were statistically significant(P<0.05).After treatment,albumin and total protein levels in the treatment group were higher than those in the general group,and the difference was statistically significant(P<0.05).The remission rate of the treatment group was 97.56%,which was higher than that of the general group,and the difference was statistically significant(χ^(2)=4.986,P<0.05).The incidence of adverse reactions in the treatment group was 4.88%,which was significantly lower than that in the general group,and the differences were statistically significant(χ^(2)=8.022,P<0.05).Conclusion Cyclophosphamide impact therapy has less adverse reactions,can improve renal function,reduce liver damage,and increase the remission rate of nephrotic syndrome in children.

关 键 词：环磷酰胺 远期疗效 肾病综合征 不良反应 冲击疗法 

分 类 号：R4[医药卫生—临床医学]