系统性红斑狼疮患者血清IgG水平表达及其同肾功能损伤的相关性  

Expression of Serum IgG in Patients with Systemic Lupus Erythematosus and Its Correlation with Renal Function Impairment

作　　者：王伟 王姝姝 倪倩 WANG Wei;WANG Shushu;NI Qian(Department of Clinical Laboratory,Yancheng First People's Hospital,Yancheng,Jiangsu Province,224000 China)

机构地区：[1]盐城市第一人民医院检验科,江苏盐城224000

出　　处：《系统医学》2023年第15期29-32,共4页Systems Medicine

摘　　要：目的分析系统性红斑狼疮(systemic lupus erythematosus,SLE)患者血清免疫球蛋白G(immunoglobulin G,IgG)水平表达及其同肾功能损伤的相关性。方法回顾性分析盐城市第一人民医院检验科2022年1月—2023年3月收治的SLE患者200例的临床资料为研究对象,依据是否发生肾功能损伤情况分为损伤组(n=80)、非损伤组(n=120)两个亚组,另选取同期进行健康体检者90例为对照组,对比分析各组患者血清IgG水平,同时对比损伤组与非损伤组患者血肌酐(serum creatinine,Scr)、降钙素原(procalcitonin,PCT)、尿素氮(blood urea nitrogen,BUN)及尿酸(uric acid,UA)水平,采用Pearson相关性分析血清IgG同肾功能指标的相关性。结果与对照组相比,损伤组、非损伤组IgG、免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白M(immunoglobulin M,IgM)水平较高,差异有统计学意义(P<0.05)。与非损伤组相比,损伤组IgG、免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白M(immunoglobulin M,IgM)水平较高,差异有统计学意义(P<0.05)。损伤组Scr、PCT、BUN、UA水平均高于非损伤组,差异有统计学意义(P<0.05)。200例SLE组患者中IgG降低者(<7.51 g/L)15例,正常者(7.51~15.20 g/L)100例,升高者(>15.20 g/L)85例。血清IgG水平与Scr、PCT、BUN、UA水平呈正相关性(r=0.49、0.60、0.41、0.50,P<0.05)。结论血清IgG水平能有效反映SLE患者肾损伤状况,对评估SLE患者肾功能存在积极影响。Objective To analyze the expression of serum immunoglobulin G(IgG)levels in patients with systemic lupus erythematosus(SLE)and its correlation with renal function damage.Methods A retrospective analysis was conducted on 200 SLE patients,clinical data,they admitted to the Laboratory of Yancheng First People's Hospital from January 2022 to March 2023.They were divided into two subgroups based on whether renal function injury occurred:the injury group(n=80)and the non injury group(n=120).Additionally,90 healthy examinees who underwent physical examination at the same time were selected as the control group.The serum IgG levels of each group of patients were compared and analyzed,and the serum creatinine(Scr)of the injury group and non injury group of patients was compared.The levels of procalcitonin(PCT),blood urea nitrogen(BUN),and uric acid(UA)were analyzed,using Pearson correlation to determine the correlation between serum IgG and renal function indicators.Results Compared with the control group,the levels of IgG,IgA,and IgM in the injury group and non injury group were higher,and the difference was statistically significant(P<0.05).Compared with the non injury group,the injury group had higher levels of IgG,IgA,and IgM,and the difference was statistically significant(P<0.05).The levels of Scr,PCT,BUN,and UA in the injury group were higher than those in the non injury group,the difference was statistically significant(P<0.05).Among the 200 SLE patients,15 had a decrease in IgG(<7.51 g/L),100 had normal IgG(7.51-15.20 g/L),and 85 had an increase(>15.20 g/L).The serum IgG level was positively correlated with the levels of Scr,PCT,BUN,and UA(r=0.49,0.60,0.41,0.50,P<0.05).Conclusion Serum IgG level can effectively reflect the status of kidney injury in SLE patients,and has a positive impact on the assessment of kidney function in SLE patients.

关 键 词：系统性红斑狼疮 免疫球蛋白 肾功能损伤 相关性 

分 类 号：R446.1[医药卫生—诊断学]