放射治疗引起的心脏微血管损伤作用机制研究进展  

Research progress on the mechanism of cardiac microvascularinjury induced by radiation therapy

作　　者：夏梦佳(综述) 刘赛 朱海涛[1] 曹雄锋(审校) XIA Mengjia;LIU Sai;ZHU Haitao;CAO Xiongfeng(Department of Image,Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu 212001,China)

机构地区：[1]江苏大学附属医院影像科,江苏镇江212001

出　　处：《现代医药卫生》2023年第19期3320-3324,共5页Journal of Modern Medicine & Health

基　　金：国家自然科学基金项目(82071984);江苏大学大学生创新创业训练计划项目(2022102991220X)。

摘　　要：心脏微血管损伤是胸部肿瘤放射治疗(放疗)的严重并发症之一,也是导致继发性心肌病、冠状动脉相关疾病、心脏传导系统异常和心包疾病等放射性心脏毒性(RICT)的病理基础。明确放疗引起的心脏微血管损伤机制对RICT的早期预防和精准化诊疗决策的制定有重大意义。该文从放疗引起的心脏微血管损伤形式、机制及其与RICT相关性等方面进行了综述,旨在为RICT的预防与监测提供新参考依据。Cardiac microvascular injury is one of the serious complications of radiation therapy(radiotherapy)for chest tumors,and it is also the pathological basis for radiation-induced cardiotoxicity(RICT)such as secondary cardiomyopathy,coronary artery related diseases,cardiac conduction system abnormalities,and pericardial diseases.Clarifying the mechanism of cardiac microvascular injury caused by radiotherapy is of great significance for the early prevention and the formulation of precise diagnosis and treatment decisions of RICT.The article reviews the forms,mechanisms,and correlation with RICT of cardiac microvascular injury caused by radiotherapy,aiming to provide new reference for the prevention and monitoring of RICT.

关 键 词：微血管损伤 放射治疗 放射性心脏毒性 综述 

分 类 号：R543[医药卫生—心血管疾病]