心脉隆注射液联合贝那普利治疗高血压伴心力衰竭的疗效探讨  

Discussion on the Efficacy of Xinmailong Injection Combined with Benazepril in the Treatment of Hypertension with Heart Failure

作　　者：刘慧慧 严建军 周文杰[1] LIU Huihui;YAN Jianjun;ZHOU Wenjie(Department of Cardiovascular Medicine,Rugao People´s Hospital,Rugao,Jiangsu Province,226500 China)

机构地区：[1]如皋市人民医院心血管内科,江苏如皋226500

出　　处：《中外医疗》2023年第22期123-127,共5页China & Foreign Medical Treatment

摘　　要：目的探讨心脉隆注射液联合贝那普利治疗高血压伴心力衰竭的临床疗效。方法方便选取2021年1月—2023年2月如皋市人民医院心血管内科收治的110例高血压伴心力衰竭患者为研究对象,按照随机数表法分为对照组和研究组,各55例。两组均给予常规抗心衰治疗,在此基础上对照组给予贝那普利治疗,研究组给予心脉隆注射液联合贝那普利治疗,两组均连续治疗14 d。比较两组患者血压、超声心功能指标、神经内分泌激素水平及临床疗效。结果治疗后,研究组的收缩压、舒张压低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组的左心室射血分数、左心室舒张早期和晚期充盈速度比值高于对照组,而左心室舒张末期内径、左室收缩末内径低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组的去甲肾上腺素、醛固酮、血管紧张素Ⅱ、肾素活性水平低于对照组,差异有统计学意义(P<0.05)。研究组的治疗总有效率(89.09%)高于对照组(72.73%),差异有统计学意义(χ^(2)=4.767,P<0.05)。结论心脉隆注射液联合贝那普利治疗高血压伴心力衰竭的疗效更好,可有效控制患者的血压,降低神经内分泌激素水平,改善患者心功能。Objective To explore the clinical efficacy of Xinmailong injection combined with benazepril in the treatment of hypertension with heart failure.Methods A total of 110 patients with hypertension and heart failure admitted to the Department of Cardiology of Rugao People's Hospital from January 2021 to February 2023 were conveniently selected as the research objects.According to the random number table method,they were divided into control group and study group,with 55 cases in each group.Both groups were given conventional anti-heart failure treatment.On this basis,the control group was treated with benazepril,and the study group was treated with Xinmailong injection combined with benazepril.Both groups were treated continuously for 14 days.The blood pressure,ultrasonic cardiac function indexes,neuroendocrine hormone levels and clinical efficacy were compared between the two groups.Results After treatment,the systolic blood pressure and diastolic blood pressure in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the left ventricular ejection fraction and the ratio of left ventricular early and late diastolic filling velocity in the study group were higher than those in the control group,while the left ventricular end-diastolic diameter and left ventricular end-systolic diameter were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of norepinephrine,aldosterone,angiotensin II and renin activity in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group(89.09%)was higher than that in the control group(72.73%),and the difference was statistically significant(χ^(2)=4.767,P<0.05).Conclusion Xinmailong injection combined with benazepril has better efficacy in the treatment of hy-pertension with heart failure,which can effectively control the patient´s blood

关 键 词：心脉隆注射液 心力衰竭 贝那普利 高血压 神经内分泌激素 疗效 

分 类 号：R541.6[医药卫生—心血管疾病]