中医临床试验文献知识本体的构建  

Construction of Literature Knowledge Ontology for Traditional Chinese Medicine Clinical Trials:A Review

作　　者：陈琦 李芹[1] 张君冬 刘丽红[1] 杨硕[1] CHEN Qi;LI Qin;ZHANG Jundong;LIU Lihong;YANG Shuo(Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;School of Information Management,Nanjing University,Nanjing 210000,China)

机构地区：[1]中国中医科学院中医药信息研究所,北京100700 [2]南京大学信息管理学院,南京210000

出　　处：《中国实验方剂学杂志》2023年第20期190-197,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82274681);中国中医科学院科技创新工程项目(CI2021A05309)。

摘　　要：目的:为有效组织中医临床试验文献中蕴含的中医和循证医学交叉学科知识,便于对多源数据进行处理和映射,该文通过本体建模实现对中医临床试验文献的知识组织。方法:使用七步法和骨架法结合进行本体开发,通过分析中医临床试验文献的结构和语言特点,复用科学证据来源信息本体(SEPIO)顶层框架和中医药语言系统(TCMLS)等本体资源和非本体资源,确定领域概念和属性关系,最终确定疾病、证候、症状、分组、干预措施、结局指标、文献质量信息等核心概念和属性关系。结果:将中医临床试验文献中所蕴含的信息分为5类,根据Cochra ne ROB偏倚风险评估工具和CONSORT 2010声明等资源,将文献质量评价信息映射到本体中,共建立了68个类,8个对象属性,38个数据属性,基本实现了临床试验文献结构化表达。结论:研究构建的中医临床试验文献本体能够更好地组织、利用和呈现中医临床试验文献内部知识体系的构建和关联,为后续证据强度及诊疗信息推理的实现奠定良好的基础。Objective:To effectively organize the interdisciplinary knowledge of traditional Chinese medicine(TCM)and evidence-based medicine contained in the clinical trial literature of TCM and facilitate the processing and mapping of multi-source data,this paper organized the knowledge of clinical trial literature of TCM by ontology modeling.Method:The seven-step method and skeleton method were used to develop the ontology.After the structure and language characteristics of TCM clinical trial literature were analyzed,the ontological and non-ontological resources such as top-level framework of Scientific Evidence and Provenance Information Ontology(SEPIO)and TCM language system(TCMLS)were reused to determine the domain concepts and attribute relationship.Finally,the core concepts and attribute relationship such as disease,syndrome,symptom,grouping,intervention measures,outcome indicators and literature quality information were determined.Result:The information contained in the clinical trial literature of TCM was divided into five categories.According to the Cochrane risk of bias assessment tool and CONSORT 2010 statement,the literature quality evaluation information was mapped to the ontology,and a total of 68 categories,8 object attributes,and 38 data attributes were established,which basically realized the structured expression of clinical trial literature.Conclusion:The ontology of TCM clinical trial literature constructed in this study can well organize,utilize,and present the construction and association of internal knowledge system in TCM clinical trial literature,underpinning the reasoning of strength of evidence and information of diagnosis and treatment in the future.

关 键 词：中医 临床试验文献 本体 语义网络 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学] R289R287R22R2-031R33R24