Spinal cord conduits for spinal cord injury regeneration  

作　　者：Yanyu Ma Quanchi Chen Wenhan Li Haiwen Su Song Li Yitong Zhu Jie Zhou Zhenhua Feng Zhen Liu Saihu Mao Yong Qiu Huan Wang Zezhang Zhu 

机构地区：[1]Division of Spine Surgery,Department of Orthopedic Surgery,Affiliated Drum Tower Hospital,Medical School,Nanjing University,Nanjing,210008,China [2]Division of Spine Surgery,Department of Orthopedic Surgery,Affiliated Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine,Nanjing,210008,China [3]Department of Nephrology,Affiliated Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine,Nanjing,210008,China [4]Division of Spine Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing,210008,China [5]The Eighth Affiliated Hospital,Sun Yat-Sen University,Shenzhen,518033,China

出　　处：《Engineered Regeneration》2023年第1期68-80,共13页再生工程（英文）

基　　金：supported by National Natural Science Foundation of China (81972029;82102637);China Post-doctoral Science Foundation (2021M701675);Jiangsu Province 333 Talent Grant (2016-III-0114);Jiangsu commission of health (K2019009);Guangdong Basic and Applied Basic Research Foundation (2019A1515111155);the Shenzhen Fundamental Research Program (JCYJ20190808120405672);Public Health and Welfare Research Project of Futian District of Shenzhen (FTWS2022013).

摘　　要：Spinal cord injury(SCI),which causes irreversible damage in both sensory and motor function,is considered an insurmountable challenge in the field of medicine.The previous researchers have developed many kinds of biomaterials for SCI,and spinal cord conduits(SCCs)are an important classification for bridging spinal cord tissues while performing their corresponding functions.In this review,we first describe the original sources of the different polymers that determine the properties of the different SCCs.Afterwards,we focus on the different types of crosslinking methods used for preparing SCCs.Then,various practical applications and therapeutic effects of SCCs are summarized and discussed.Finally,we conclude the existing limitations of current SCCs.We hope that this paper will serve as a further inspiration for the development of SCCs in future.

关 键 词：Spinal cord injury Neuron regeneration Hydrogel Spinal cord conduit Tissue engineering 

分 类 号：R651.2[医药卫生—外科学]