Chronic wounds:pathological characteristics and their stem cell-based therapies  

作　　者：Xiangyi Wu Haofang Zhu Ye Xu Bin Kong Qian Tan 

机构地区：[1]Department of Burns and Plastic Surgery,Institute of Translational Medicine,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210002,China [2]Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging,Department of Biomedical Engineering School of Medicine,Shenzhen University,Shenzhen 518060,China

出　　处：《Engineered Regeneration》2023年第1期81-94,共14页再生工程（英文）

基　　金：supported by grants from the National Natural Science Foundation of China (No.81974288);the National Natural Science Foundation of China (No.82101184);Shenzhen Fundamental Research Program (No.JCYJ20210324102809024);Shenzhen PhD Start-up Program (No.RCBS20210609103713045).

摘　　要：Chronic wounds are characterized by prolonged healing processes and poor prognoses,which have substantially impacted human health and daily life.Traditional treatment strategies have various limitations and drawbacks.Therefore,fully effective therapeutic approaches remain urgently needed.Stem cell(SC)-based therapies have drawn significant attention for their abilities of immunomodulation and pro-regeneration.It has been demon-strated that stem cells(SCs)can improve angiogenesis,collagen deposition,and hair rejuvenation,thus facilitating wound healing.In addition,attempts were performed to facilitate the cell survival,function,retention,and en-graftment of the delivered SCs.In this review,we first introduce the pathological process involved in chronic wound healing.Following that,the mechanism of SCs in promoting chronic wound repair is discussed in detail.Then,we highlight recent SC-based therapies for chronic wound repair developments.Finally,we present our views on the remaining challenges and future trends of SC-based therapies for chronic wound treatment.

关 键 词：Chronic wounds Stem cell Cell scaffold Cell-free therapy Gene modification 

分 类 号：R318.04[医药卫生—生物医学工程]