探讨濮阳45岁以上人群血脂异常及其与冠心病发病的关联性  

Analysis of dyslipidemia and its association with the incidence of coronary heart disease in people over 45 years of age

作　　者：楚玉静 Chu Yu-jing(Puyang Huimin Hospital,Puyang 457000,Henan,China)

机构地区：[1]濮阳惠民医院,河南濮阳457000

出　　处：《四川生理科学杂志》2023年第10期1868-1871,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨45岁以上人群血脂异常及其与冠心病发病的关联性。方法:便利抽样选取2018年1月至12月来院体检的275例45岁以上人群进行随访4 y调查,以是否存在冠心病分为冠心病组和非冠心病组,分析血脂异常与冠心病发病的关联性。结果:275名45岁以上体检者冠心病90例,累计发病率为32.73%,其中高甘油三酯血症占20例,占比7.27%、高总胆固醇血症占23例,占比8.36%、高LDL-C血症21例,占7.64%、低HDL-C血症47例,占16.73%;男女血脂异常患病率比较差异有统计学意义(P<0.05);冠心病组甘油三酯、总胆固醇、高密度脂蛋白胆固醇(High density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(Low-Density Lipoprotein Cholesterol,LDL-C)、尿酸、高甘油三脂血症、高总胆固醇血症、高LDL-C血症、低HDL-C血症与非冠心病组比较差异有统计学意义(P<0.05)。多因素Cox比例风险回归分析得出:甘油三酯水平(HR:1.324,95%CI:1.083~1.617)、总胆固醇水平(HR:1.585,95%CI:1.076~2.346)、LDL-C水平(HR:1.230,95%CI:1.028~1.476)、HDL-C水平(HR:0.879,95%CI:0.432~1.065)是风险因素。结论:45岁以上人群血脂异常与冠心病发病密切相关,防止甘油三酯、总胆固醇、LDL-C水平升高、HDL-C降低或将是预防和控制冠心病发病有效措施之一。Objective:To investigate the relationship between dyslipidemia and coronary heart disease in people over 45 years old.Methods:A convenient sampling of 275 people over 45 years of age who came to our hospital for physical examination from January to December 2018 was conducted for a 4-year follow-up investigation.According to the presence of coronary heart disease,they were divided into coronary heart disease group and non-coronary heart disease group,and the correlation between dyslipidemia and the incidence of coronary heart disease was analyzed.Results:There were 90 cases of coronary heart disease in 275 people over 45 years old for physical examination,with a cumulative incidence rate of 32.73%,of which 20 cases were hypertriglyceridemia,accounting for 7.27%,23 cases were hypercholesterolemia,accounting for 8.36%,21 cases were high LDL-C,accounting for 7.64%,and 47 cases were low HDL-C,accounting for 16.73%;There was a statistically significant difference in the prevalence of dyslipidemia between males and females(P<0.05);There was a statistically significant difference in triglycerides,total cholesterol,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),uric acid,high triglyceridemic,high total cholesterol,high LDL-C,and low HDL-C between the coronary heart disease group and the non coronary heart disease group(P<0.05).Multivariate Cox proportional risk regression analysis showed that triglyceride levels(HR:1.324,95%CI:1.083~1.617),total cholesterol levels(HR:1.585,95%CI:1.076~2.346),LDL-C levels(HR:1.230,95%CI:1.028~1.476),and HDL-C levels(HR:0.879,95%CI:0.432~1.065)were risk factors.Conclusion:Dyslipidemia in people over 45 years old is closely related to the incidence of coronary heart disease.Preventing the increase of triglyceride,total cholesterol,LDL-C and the decrease of HDL-C may be one of the effective measures to prevent and control the incidence of coronary heart disease.

关 键 词：脂异常 冠心病 关联性 

分 类 号：R541.4[医药卫生—心血管疾病]