Synthesis of chiral allylic phosphonates via asymmetric reductive cross-coupling of α-bromophosphonates and vinyl bromides  

作　　者：Hepan Wang Xinxuan Li Tao XU 

机构地区：[1]Shanghai Key Laboratory of Chemical Assessment and Sustainability,School of Chemical Science and Engineering,Tongji University,Shanghai 200092,China

出　　处：《Science China Chemistry》2023年第9期2621-2625,共5页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (22071183);the Science and Technology Commission of Shanghai Municipality (19DZ2271500)。

摘　　要：Chiral phosphine-containing skeletons play a pivotal role in bioactive natural products, pharmaceuticals, chiral catalysts, and ligands. Despite considerable progress has been made in the synthesis of chiral phosphorus compounds, the development of facile and modular methods to access chiral allylic phosphorus compounds remains challenging due to the simultaneous control required for reactivity, enantioselectivity, and stereoselectivity. Herein, we present a general and modular platform to achieve the asymmetric reductive cross-coupling of α-bromophosphonates and vinyl bromides, enabling the synthesis of highly valuable chiral allylic phosphonate products with remarkable yields, enantioselectivities, and stereoselectivities.

关 键 词：chiral phosphorus compound reductive cross-coupling α-alkenyl phosphonate nickel asymmetric reaction 

分 类 号：TQ265.1[化学工程—有机化工]