核因子E2相关因子2介导的氧化应激在糖尿病肾脏疾病肾纤维化中的研究进展  

Research progress of Nrf2 in oxidative stress-induced renal fibrosis in diabetic kidney disease

作　　者：林千愉 李梦洁 梁栋 张慧[1] 张晓敏[1] LIN Qianyu;LI Mengjie;LIANG Dong(Department of Nephrology,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院肾内科,256600

出　　处：《中国糖尿病杂志》2023年第8期627-631,共5页Chinese Journal of Diabetes

基　　金：滨州医学院科技计划项目(BY2021KJ07)。

摘　　要：肾纤维化是DKD终末期不可逆的肾脏病理变化,氧化应激(OS)在肾纤维化中起重要作用。核因子E2相关因子2(Nrf2)是维持氧化还原动态平衡的关键转录因子。本文综述Nrf2介导的OS在DKD肾纤维化中的研究进展。Renal fibrosis is an irreversible renal pathological change in the end stage of diabetic kidney disease(DKD).Oxidative stress(OS)plays a crucial role in the etiology of renal fibrosis.Nuclear factor E2-related factor 2(Nrf2)is a key transcription factor that maintains redox dynamic balance.This article reviews the research progress of Nrf2 mediated OS in DKD renal fibrosis.

关 键 词：糖尿病肾脏疾病 核因子E2相关因子2 氧化应激 肾纤维化 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]