Multicomponent cascade reaction of 3-formylchromones:Highly regioselective synthesis of functionalized pyridin-2(1H)-ones  

作　　者：Xinghan Yun Li Chen Ying Lv Zihan Lu Kun Huang Shengjiao Yan 

机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resource(Yunnan University),Ministry of Education,School of Chemical Science and Technology,Yunnan University,Kunming,650091,China

出　　处：《Green Synthesis and Catalysis》2023年第3期231-239,共9页绿色合成与催化（英文）

基　　金：support from the Natural Science Foundation of Yunnan Province(No.2019FY003003);the National Natural Science Foundation of China(No.21662042);the Scientific and Technological Innovation Team of Green Synthesis and Activity Research of Natural-like Heterocyclic Compound Libraries in Universities of Yunnan Province(No.C17624011121).

摘　　要：A novel protocol was developed for the construction of highly functionalized pyridin-2(1H)-ones from 3-formylchromones,ethyl 2-(pyridin-2-yl)acetate derivatives and amines via a complex multicomponent cascade reaction involving targeted duplicated ring-opening and duplicated cyclization reactions which form skeleton-reorganized target compounds.A series of pyridin-2(1H)-ones were produced by this reaction accompanied by the formation of three bonds(one C–N and two C–C bonds)and the cleavage of one bond in one step.This protocol can be used in combinatorial and parallel syntheses of various pyridin-2(1H)-ones with potent biological activity.The advantages of this approach include simple and practical operation(multicomponent one-pot),high yields(up to 91%),and products with potential biological activity.

关 键 词：Pyridin-2(1H)-ones Cascade reaction Selective synthesis 3-Formylchromones 

分 类 号：O621[理学—有机化学]