Contemporary synthesis of bioactive cyclobutane natural products  

作　　者：Chunngai Hui Zhuo Wang Yusheng Xie Junyang Liu 

机构地区：[1]Max Planck Institute of Molecular Physiology,Department of Chemical Biology,Dortmund 44227,Germany [2]Technical University Dortmund,Faculty of Chemistry and Chemical Biology,Dortmund 44221,Germany [3]School of Biotechnology and Health Sciences,Wuyi University,Jiangmen,Guangdong 529020,China [4]Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen 518055,China [5]Southern University of Science and Technology,School of Medicine,Shenzhen 518005,China [6]Department of Pharmacology,School of Basic Medical Sciences,Shandong University,Jinan 250012,China

出　　处：《Green Synthesis and Catalysis》2023年第1期1-6,共6页绿色合成与催化（英文）

基　　金：J.Liu acknowledges the support of the Guangdong Basic and Applied Basic Research Foundation(No.2021A1515010188);the Shenzhen Science and Technology Innovation Committee(No.JCYJ20190809181011411);the Guangdong Department of Education(No.2021ZDJS097);Y.Xie gratefully acknowledges the financial support from the National Natural Science Foundation of China(No.22107058).

摘　　要：Many cyclobutane natural products have intriguing biological properties that arise from their fascinating chemical structures.Cyclobutane natural products feature a cyclobutane scaffold as the core or as a part of the spirocyclic or fused cyclic core.However,the highly functionalized nature and the inherent stereochemistry of these cyclobutane natural products,which are associated with their biological activities,pose tremendous challenges to their preparation.In this perspective,we present contemporary advancements in synthetic methods and/or strategies en route to the bioactive cyclobutane natural products.We begin by describing the representative bioactive cyclobutane natural products and then focus on illustrative examples of their syntheses reported from 2018 to 2021.These advances will enable efficient syntheses of cyclobutanes of structural and biological importance.

关 键 词：CYCLOBUTANE Natural products Bioactive Synthetic methodology Chemical synthesis 

分 类 号：O62[理学—有机化学]