Controllable cross-coupling of thiophenols with dichloromethane mediated by consecutively paired electrolysis  

作　　者：Ting Zeng Jianjing Yang Kelu Yan Wei Wei Jiangwei Wen 

机构地区：[1]Institute of Medicine and Materials Applied Technologies,College of Chemistry and Chemical Engineering,Qufu Normal University,Qufu 273165,China [2]Qinghai Provincial Key Laboratory of Tibetan Medicine Research and CAS Key Laboratory of Tibetan Medicine Research,Northwest Institute of Plateau Biology,Qinghai 810008,China

出　　处：《Green Synthesis and Catalysis》2023年第1期35-40,共6页绿色合成与催化（英文）

基　　金：This work is supported by the National Natural Science Foundation of China(No.21902083);the Natural Science Foundation of Shandong Province(No.ZR2020QB130);This work is also supported by the Talent Program Foundation of Qufu Normal University(Nos.6132 and 6125).

摘　　要：Chloroalkanes are important building blocks in the synthesis,but their use in redox chemistry is limited by their negative reduction potentials.Electrosynthesis can precisely control the reaction energy just by adjusting the current or voltage to achieve the selectivity of regulation.In this study,the consecutively paired electrolyticmediated controllable radical cross-coupling of thiophenols with dichloromethane was developed to deliver the dithioacetals,sulfides,and sulfoxides in the absence of electrochemical mediator conditions.It features broad substrate scope,simple operation,gram-scale synthesis,and is eco-friendly.Mechanistic studies reveal that this electrochemical reaction is radical-induced cross-coupling of thiophenols with dichloromethane.

关 键 词：Paired electrolytic CROSS-COUPLING DICHLOROMETHANE THIOPHENOLS DITHIOACETALS SULFOXIDES 

分 类 号：O62[理学—有机化学]