Sulfur-promoted,one-pot,and metal-free conversion of aromatic aldehydes to nitriles using an inorganic ammonium salt as the nitrogen source  

作　　者：Jiawen Yin Xia Meng Changqun Cai Lingyun Wang Hang Gong 

机构地区：[1]The Key Laboratory for Green Organic Synthesis and Application of Hunan Province,Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan 411105,China [2]School of Material and Chemical Engineering,Hunan Institute of Technology,Hengyang 421002,China

出　　处：《Green Synthesis and Catalysis》2023年第1期46-53,共8页绿色合成与催化（英文）

基　　金：This work was supported by the Key Project Program of the Educational Department of Hunan Province(No.18A069);the Postgraduate Scientific Research Innovation Project of Hunan Province(No.QL20210148);the Scientific Research Foundation of Hunan Provincial Education Department(No.19C0522);the Scientific Research Foundation of Hunan Institute of Technology(No.2018HY011);the Project of Innovation Team of the Ministry of Education(No.IRT_17R90);Hunan 2011 Collaborative Innovation Center of Chemical Engineering&Technology with Environmental Benignity and Effective Resource Utilization.

摘　　要：A simple protocol for the sulfur-promoted conversion of aromatic aldehydes to aromatic nitriles has been developed.This strategy enables the one-pot conversion of inexpensive and readily available aromatic aldehydes into highly valuable aromatic nitriles using a cheap inorganic ammonium salt as the nitrogen source in the absence of metals.Significantly,a broad scope of substrates was explored using this strategy,and various groups,including alkyl,alkoxyl,alkylthiol,hydroxyl,amino,aryl,alkenyl,cyano,carboxyl,and borate ester groups were tolerated,and good to excellent yields were achieved in most cases.Additionally,polycyclic aromatic aldehydes and heteroaromatic aldehydes also could be converted to the corre-sponding nitriles with satisfactory yields.This method can be utilized as a powerful tool for the cyanation of complex molecules.

关 键 词：Synthetic methodology Transition-metal free NITRILES ALDEHYDES One-step reaction 

分 类 号：O62[理学—有机化学]