Electrochemically mediated three-component synthesis of isothioureas using thiols as sulfur source  

作　　者：Muxue He Pingfu Zhong Hanfu Liu Chuhong Ou Yingming Pan Haitao Tang 

机构地区：[1]State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University,Guilin 541004,China [2]Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health,School of Public Health of Guilin Medical University,Guilin 541199,China

出　　处：《Green Synthesis and Catalysis》2023年第1期41-45,共5页绿色合成与催化（英文）

基　　金：We thank the financial support from the National Natural Science Foundation of China(Nos.22061003 and 22161008);the Natural Science Foundation of Guangxi Province(Nos.2021GXNSFFA220005 and 2021GXNSFBA196041).

摘　　要：The simultaneous binding/dissociation of multiple bonds in a one-pot manner by multicomponent reactions provide an important approach for developing novel and sustainable pathway in the drug discovery process.Herein we develop an electrocatalytic three-component reaction to construct multifunctional and valuable isothiourea compounds,which uses thiols,isocyanides and amines as substrates.Compared with the previous work,the organic electrosynthesis technique can avoid the requirement of heavy metal catalysts and stoichiometric oxidants.In addition,using thiol as a substrate to participate in the three-component reaction broadens the source of sulfur,which can also construct more abundant isothiourea derivatives.

关 键 词：Multicomponent reaction Isothiourea Organic electrosynthesis THIOL 

分 类 号：O62[理学—有机化学]