Heating-induced decarboxylative cyclization for the synthesis of 5-trifluoromethyl-1,2,4-triazoles from trifluoroacetimidohydrazides andα-oxocarboxylic acids  

作　　者：Yu Zhang Guangming Wei Shiqi Qiu Zhengkai Chen Xiao Feng Wu 

机构地区：[1]Department of Chemistry,Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang Province,Zhejiang Sci-Tech University,Hangzhou 310018,China [2]Dalian National Laboratory for Clean Energy,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China [3]Leibniz-Institut für Katalyse e.V.,Albert-Einstein-Straβe 29a,Rostock 18059,Germany

出　　处：《Green Synthesis and Catalysis》2023年第2期177-180,共4页绿色合成与催化（英文）

基　　金：support from the Natural Science Foundation of Zhejiang Province(No.LY19B020016);the K.C.Wong Education Foundation(No.GJTD-2020-08).

摘　　要：A simple metal and additive-free approach for the assembly of 5-trifluoromethyl-1,2,4-triazoles via only heatinginduced decarboxylative cyclization of readily available trifluoroacetimidohydrazides andα-oxocarboxylic acids has been developed.In this protocol,the rarely reported tetrahedral carboxylic acids intermediate could be in-situ generated and undergo subsequent decarboxylation to afford the target heterocycle products.

关 键 词：Heating-induced Decarboxylative cyclization 5-Trifluoromethyl-1 2 4-triazoles Trifluoroacetimidohydrazides α-Oxocarboxylic acids Trifluoromethyl-substituted N-heterocycles 

分 类 号：X703[环境科学与工程—环境工程]