Cellular polyploidy in organ homeostasis and regeneration  

作　　者：Juntao Fang Alain de Bruin Andreas Villunger Raymond Schiffelers Zhiyong Lei Joost P.G.Sluijter 

机构地区：[1]Department of Experimental Cardiology,University Medical Center Utrecht,Heidelberglaan 100,3584 CX Utrecht,The Netherlands [2]Department of Pediatrics,University of Groningen,PO Box 30.001,9700 RB Groningen,The Netherlands [3]Department of Pathobiology,Dutch Molecular Pathology Center,Utrecht University,Yalelaan1,3584 CL Utrecht,The Netherlands [4]Institute for Developmental Immunology,Biocenter,Medical University of Innsbruck,Innrain 80,6020 Innsbruck,Austria [5]Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases,Lazarettgasse 14,AKH BT 25.3 c/o CeMM Research Building,Haupteingang Level 1,1090 Wien,Osterreich [6]CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences,Lazarettgasse 14,AKH BT 25.3,A-1090 Vienna,Austria [7]CDL Research,University Medical Center Utrecht,Heidelberglaan 100,3584 CX Utrecht,The Netherlands

出　　处：《Protein & Cell》2023年第8期560-578,共19页蛋白质与细胞（英文版）

基　　金：supported by the Project EVICARE (No.725229)of the European Research Council (ERC)to J.P.G.S.;the ZonMw-TAS program (No.116002016)to J.P.G.S./Z.L.;the Dutch Ministry of Economic Affairs,Agriculture and Innovation and the Netherlands CardioVascular Research Initiative (CVON);the Dutch Heart Foundation to J.P.G.S.Juntao Fang is supported by a Chinese Scholarship Council (CSC)fellowship program (No.201906210082).AV acknowledges support by the ERC;AdG 787171,POLICE.

摘　　要：Polyploid cells,which contain more than one set of chromosome pairs,are very common in nature.Polyploidy can provide cells with several potential benefits over their diploid counterparts,including an increase in cell size,contributing to organ growth and tissue homeostasis,and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals.Here,we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid.Moreover,we discuss its crucial roles in cell growth and tissue regeneration in the heart,liver,and other tissues.

关 键 词：cellular polyploidy tissue regeneration cardiac regeneration liver regeneration 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]