1994年至2020年我国孕产妇死胎发生率的Meta分析  

A Meta Analysis of the Incidence of Stillbirth in Pregnant and Postpartum Women in China from 1994 to 2020

作　　者：王华平 游顶云 杨雁鸿 陈博文 环越 廖芮 Huaping WANG;Dingyun YOU;Yanhong YANG;Bowen CHEN;Yue HUAN;Rui LIAO(The Library,Kunming Medical University,Kunming Yunnan 650500,China;Dept.of Public Health,Kunming Medical University,Kunming Yunnan 650500,China;Dept.of The 1st Clinical College,Kunming Medical University,Kunming Yunnan 650500,China)

机构地区：[1]昆明医科大学图书馆,云南昆明650500 [2]昆明医科大学公共卫生学院,云南昆明650500 [3]昆明医科大学第一临床学院,云南昆明650500

出　　处：《昆明医科大学学报》2023年第9期15-24,共10页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81660545);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE468(-013)]。

摘　　要：目的系统评价并描述我国1994年1月至2022年5月间孕产妇死胎率(Stillbirth rate)及不同地区孕产妇中死胎率的总体估计,为进一步降低死胎发生率采取因地制宜的围产期管理策略提供支持和依据。方法计算机检索4大主流高质量英文数据库(即PubMed、Cochrane library、Web of Science、EMBASE)及4大中文核心数据库(中国知网,中国生物医学文献数据库、维普及万方数据库),搜集建库至2022年4月30日发表的有关我国孕产妇人群死胎(包含死产)率的队列及横断面研究,采用STATA 16.0软件进行Meta分析。结果共纳入200篇文献,合计纳入研究的总样本量22455289例。Meta分析结果显示,我国死胎发生率为6‰[95%CI(6‰,7‰)]。亚组分析显示,不同地区孕产妇死胎率之间存在差异(χ^(2)=392.00,P<0.001)。西部地区孕产妇人群死胎率最高为9‰[95%CI(8‰,9‰)]。其次是中部地区为8‰[95%CI(6‰,9‰)],最后是东部和东北地区为6‰[95%CI(6‰,6‰),(5‰,7‰)]。前10 a(1994年至2005年)、后10 a(2006年至2016年)及最近3 a(2017年至2020年)我国孕产妇死胎率之间存在差异(χ^(2)=302.00,P<0.001)。1994年至2005年的死胎率为8‰[95%CI(7‰,8‰)],高于2006年至2016年的死胎率,为6‰[95%CI(5‰,6‰)],最近3 a(2017年至2020年)的死胎率最低,为5‰[95%CI(4‰,6‰)]。结论1994年至2020年间我国孕产妇死胎率为6‰,西部地区死胎率较高为9‰。1994年至2020年间前后10 a及最近3 a的死胎率呈下降趋势。Objective To systematically analyse and describe the overall stillbirth rate in different regions of the Chinese mainland from 1994 to 2020 so as to provide the basis for further reducing the stillbirth rate and formulating perinatal management strategies suitable for different regions.Methods Databases including PubMed,Cochrane library,Web of Science,EMBASE,SinoMed,CNKI,VIP and WanFang Data were electronically searched to collect the cohort and cross-sectional studies on the stillbirth rate among the pregnant females in the Chinese mainland from building date to April30,2022.Results A total of 200 literatures were included,with a total sample size of 22,455,289 cases in the study.Results of meta-analysis showed that the overall stillbirth rate among the pregnant females in the Chinese mainland was 6‰[95%CI(6‰,7‰)].Subgroup analysis showed that there were differences in the stillbirth rates between the different regions(χ^(2)=392.00,P<0.001),and that stillbirth rate among the pregnant females in western China was the highest 9‰[95%CI(8‰,9‰)],followed by the central region with 8‰[95%CI(6‰,9‰)],and the eastern and northeastern regions with 6‰[95%CI(6‰,6‰),(5‰,7‰)].There were differences in the stillbirth rate in the first 10 years(1994-2005),the second 10 years(2006-2016)and the past three years(2017-2020)in the Chinese mainland(χ^(2)=113.00,P<0.001).The stillbirth rate in 1994-2005 was 8‰[95%CI(7‰,8‰)],which was higher than that in 2006-2016(6‰,[95%CI(5‰,6‰)]).The stillbirth rate in the last three years(2017-2020)was the lowest 5‰,[95%CI(4‰,6‰)].Conclusion The stillbirth rate of the pregnant women in China’s mainland is 6‰while the rate in western China is higher at 9‰.The stillbirth rate is on the decline between 1994 and 2020.

关 键 词：死胎率 孕产妇 中国 META分析 

分 类 号：R714.7[医药卫生—妇产科学]