Harnessing male germline epigenomics for the genetic improvement in cattle  

作　　者：Xiao Wang Wenlong Li Xia Feng Jianbin Li George E.Liu Lingzhao Fang Ying Yu 

机构地区：[1]Laboratory of Animal Genetics and Breeding,Ministry of Agriculture and Rural Affairs of China,National Engineering Laboratory of Animal Breeding,College of Animal Science and Technology,China Agricultural University,Beijing 100193,China [2]Konge Larsen ApS,Kongens Lyngby 2800,Denmark [3]Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan 250100,China [4]Animal Genomics and Improvement Laboratory,Agricultural Research Service,Henry A.Wallace Beltsville Agricultural Research Center,USDA,Beltsville,MD 20705,USA [5]Center for Quantitative Genetics and Genomics,Aarhus University,Aarhus 8000,Denmark

出　　处：《Journal of Animal Science and Biotechnology》2023年第5期1834-1853,共20页畜牧与生物技术杂志（英文版）

基　　金：funded by the National Key R&D Program of China(2021YFD1200903);Seed Fund(CAU),Shandong Provincial Natural Science Foundation(ZR2021MC070);the National Key R&D Program of China(2021YFF1000701-06);Shandong Provincial Natural Science Foundation(ZR2020MC165);the Earmarked Fund for CARS-36.X.W.is funded by the“Hundred Talents Program”project of Hebei Province(E2020100019);the research project of Zhongnongtongchuang(ZNTC)group(ZNTC2019A10 and ZNTC2021B12)in China.

摘　　要：Sperm is essential for successful artificial insemination in dairy cattle,and its quality can be influenced by both epi-genetic modification and epigenetic inheritance.The bovine germline differentiation is characterized by epigenetic reprogramming,while intergenerational and transgenerational epigenetic inheritance can influence the offspring’s development through the transmission of epigenetic features to the offspring via the germline.Therefore,the selec-tion of bulls with superior sperm quality for the production and fertility traits requires a better understanding of the epigenetic mechanism and more accurate identifications of epigenetic biomarkers.We have comprehensively reviewed the current progress in the studies of bovine sperm epigenome in terms of both resources and biological discovery in order to provide perspectives on how to harness this valuable information for genetic improvement in the cattle breeding industry.

关 键 词：Artificial insemination CATTLE Epigenetic inheritance Genetic improvement Germline epigenomics 

分 类 号：S823[农业科学—畜牧学]