D-最优混料设计方法分析及其在制剂处方优化中的应用进展  

Analysis of D-optimal mixture design method and its application in formula optimization

作　　者：程子为 唐雨 杨曼宁 仲瑞雪 万军[1] CHENG Ziwei;TANG Yu;YANG Manning;ZHONG Ruixue;WAN Jun(Life Science&Engineering College of South-west Jiao-tong University,Chengdu 610031,China;Sichuan Provincial Orthopedic Hospital,Chengdu 610041,China)

机构地区：[1]西南交通大学生命科学与工程学院,四川成都610031 [2]四川省骨科医院,四川成都610041

出　　处：《广东药科大学学报》2023年第5期114-119,共6页Journal of Guangdong Pharmaceutical University

基　　金：中央高校基本科研业务费专项资金项目(202210613081);四川省骨科医院科研项目(2021MS03);西南交通大学个性化实验项目(GX2022160137)。

摘　　要：探寻成分或处方间的最优配比是药物制剂研究的一个重要方向之一。近年来,D-最优混料设计被广泛应用于药物制剂的研究,通过合理选择试验点,全面、高效地优化药物制剂处方从而得到最优配比,以满足制剂成型工艺的要求。本文通过查阅文献,回顾了D-最优混料设计在国内外药物制剂研究中的应用情况,重点对其基本原理、步骤及适用性进行分析,为该方法在药物制剂研发中的合理应用提供参考。Exploring the optimal ratio of ingredients or prescriptions is one of the important directions in the research of pharmaceutical preparations.In recent years,D-optimal mixture design has been widely used in the research of pharmaceutical preparations,which optimizes the formulation of pharmaceutical preparations comprehensively and efficiently by selecting reasonable test points to obtain the optimal mixture ratio,and then to meet the requirements of pharmaceutical molding processes.This article reviews the application of D-optimal mixture design in pharmaceutical research both domestically and internationally through literature review,focusing on analyzing the basic principles,steps,and applicability,which will provide a reference for the rational application of this method in pharmaceutical research and development.

关 键 词：药物制剂 D-最优混料设计 处方优化 原理 适用性分析 

分 类 号：R944.9[医药卫生—药剂学]