App-based assessment of memory functions in patients after transfemoral aortic valve replacement  

作　　者：Jonathan Nübel Michael Hauptmann Julika Schön Georg Fritz Christian Butter Anja Haase-Fielitz 

机构地区：[1]Department of Cardiology,University Hospital Heart Centre Brandenburg,Brandenburg Medical School(MHB)Theodor Fontane,Bernau,Germany [2]Institute of Biostatistics and Registry Research,Brandenburg Medical School Theodor Fontane,Neuruppin,Germany [3]Faculty of Health Sciences(FGW),Joint Faculty of the University of Potsdam,the Brandenburg Medical School Theodor Fontane and the Brandenburg Technical University Cottbus-Senftenberg,Cottbus,Germany [4]Anesthesia and Intensive Care,University Hospital Ruppin Brandenburg(ukrb),Brandenburg Medical School(MHB)Theodor Fontane,Neuruppin,Germany [5]Department of Anesthesiology,Intensive Care and Pain Therapy,University Hospital Heart Centre Brandenburg,Brandenburg Medical School(MHB)Theodor Fontane,Bernau,Germany [6]Institute of Social Medicine and Health System Research,Otto von Guericke University Magdeburg,Germany

出　　处：《Journal of Geriatric Cardiology》2023年第9期664-672,共9页老年心脏病学杂志（英文版）

基　　金：the Ministry of Science,Research and Cultural Affairs of the State of Brandenburg and the MHB publication fund supported by DFG.Jonathan Nübel declares that this work is supported by a research grant of the German Cardiac Society(DGK);the Ethics committee of the Brandenburg Medical School(MHB)E-01-20191006.

摘　　要：BACKGROUND Transfemoral aortic valve replacement(TAVR)is the standard treatment for elderly patients with aortic valve stenosis.Although safe and well-established,there is a risk of intraprocedural hemodynamic instability and silent cerebral embolism,which can lead to a decline in neurocognitive function and dementia.In clinical practice,comprehensive cognitive testing is difficult to perform.AI-assisted digital applications may help to optimize diagnosis and monitoring.METHODS Neurocognitive function was assessed by validated psychometric tests using“Δelta-App”,which uses artificial intelligence and computational linguistic methods for extraction and analysis.Memory function was assessed using the‘Consortium to Establish a Registry for Alzheimer’s Disease’(CERAD)word list and digit span task(DST)before TAVR and before hospital discharge.The study is registered in the German Register of Clinical Trials(https://drks.de/search/de/trial/DRKS00020813).RESULTS From October 2020 until March 2022,141 patients were enrolled at University Hospital Heart Centre Brandenburg.Mean age was 81±6 years,42.6%were women.Time between the pre-and post-interventional test was on average 6±3 days.Memory function before TAVR was found to be below average in relation to age and educational level.The pre-post TAVR comparison showed significant improvements in the wordlist repeat,P<0.001 and wordlist recall test of CERAD,P<0.001.There were no changes in the digital span test.CONCLUSIONS Despite impaired preoperative memory function before TAVR,no global negative effect on memory function after TVAR was detected.The improvements shown in the word list test should be interpreted as usual learning effects in this task.

关 键 词：PATIENTS IMPAIRED VALVE 

分 类 号：R654.2[医药卫生—外科学]