中药干预足细胞凋亡治疗糖尿病肾病研究进展  

Research Progress in the Treatment of Diabetic Nephropathy byInterfering Podocyte Apoptosis with Chinese Medicinal Intervention

作　　者：陆立煌 王旭[1] 朴成玉[1] 马艳春[1] 吴修红[1] LU Lihuang;WANG Xu;PIAO Chengyu;MA Yanchun;WU Xiuhong(Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药学报》2023年第10期100-105,共6页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金项目(82174274);黑龙江省中医药科研项目(ZYW2022-076)。

摘　　要：糖尿病肾病(DN)的发病机制十分复杂,足细胞丢失在其发生、发展过程中起着重要作用,可导致肾功能受损,而细胞凋亡是足细胞丢失的主要原因,因此干预足细胞凋亡对于延缓DN进程有着重要意义。中药具有多靶点及多途径的特殊优势,近来许多研究发现中药在干预足细胞凋亡方面有良好的疗效,但缺乏系统性的综述。本文对中药干预足细胞的内源性凋亡、外源性凋亡、内质网应激凋亡三条途径,抑制足细胞凋亡治疗DN进行综述,以期为今后DN的治疗提供参考。The pathogenesis of diabetic nephropathy(DN)is very complicated,and podocyte loss plays a key role in its occurrence and development,which can lead to renal function impairment.Apoptosis is the main cause of podocyte loss.Therefore,intervention of podocyte apoptosis is of great significance for delaying DN process.Chinese medicinals have advantages of multi-targets and multi-pathways.Recently,many studies have found that Chinese medicinals have good effects on podocyte apoptosis,but lack systematic review.This article reviews from three ways of Chinese medicinal intervention on podocyte apoptosis in the treatment of DN,endogenous apoptosis,exogenous apoptosis and endoplasmic reticulum stress apoptosis,in order to provide reference for the treatment of DN in the future.

关 键 词：糖尿病肾病 足细胞凋亡 中药 

分 类 号：R255.4[医药卫生—中医内科学]