黄芪多糖抗肺癌作用机制研究进展  

Research Progress on Mechanism of Astragalus Polysaccharidein Resisting Lung Cancer

作　　者：林霄月 耿雪[1] 迟文成[2] 隋雨桐 梁华[1] 姜家康[1] LIN Xiaoyue;GENG Xue;CHI Wencheng;SUI Yutong;LIANG Hua;JIANG Jiakang(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Shenzhen Hospital of Southern Medical University,Shenzhen 518110,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [3]南方医科大学深圳医院,广东深圳518110

出　　处：《中医药学报》2023年第10期106-111,共6页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金青年基金项目(82104585);黑龙江省自然科学基金面上项目(H201478);黑龙江中医药大学研究生创新基金(yjscx2017002)。

摘　　要：肺癌的高发病率与早期不明显症状使其成为医疗卫生难题,加大了后期治疗难度。当前医疗技术治疗下的患者普遍预后较差,严重影响患者生活质量。近几年,中药活性成分抗肺癌研究成为热点。中药黄芪在防治肿瘤方面具有悠久的应用历史,现代研究表明黄芪多糖抗肺癌具有显著疗效,不仅能控制癌症发展,同时提高了患者生存质量。黄芪多糖抗肺癌作用机制,包括通过调控相关通路来抑制肿瘤细胞增殖;通过关键因子和生物标志物来抑制迁移与侵袭;调节机体免疫功能,改变肿瘤微环境;抑制骨髓干细胞;正向或负向调节细胞自噬;与化疗药物或靶向药物联合使用起到增效减毒作用。本文对近年研究黄芪多糖抗肺癌作用机制进行了综述。The high incidence of lung cancer and its early inconspicuous symptoms make it more difficult to treat in the later stage.At present,the prognosis of patients treated with medical technology is generally poor,which seriously affects the life quality of the patients.In recent years,the study of active components of Chinese medicinal for lung cancer has become a hot spot.Astragalus polysaccharide has a wide range of biological activities,including inhibiting proliferation of tumor cells by regulating related pathways;inhibiting migration and invasion by key factors and biomarkers;regulating immune function of the body and changing the tumor microenvironment;inhibiting bone marrow stem cells;positively or negatively regulating autophagy;especially in combination with chemotherapy drugs or targeted drugs to achieve the effect of synergy and attenuation.This study reviewed the action mechanism of astragalus polysaccharide in resisting lung cancer.

关 键 词：中药 黄芪 多糖 肺癌 

分 类 号：R285[医药卫生—中药学]