血液灌流联合序贯透析治疗终末期肾脏疾病MDA、KT/V及Hb水平变化分析  

Analysis of MDA,KT/V,and Hb levels in patients with end⁃stage renal disease treated with hemoperfusion combined with sequential dialysis

作　　者：孙丽悦 王兰香 张颖 张锡友 SUN Liyue;WANG Lanxiang;ZHANG Ying;ZHANG Xiyou(Department of Dialysis Room,Beijing Shijitan Hospital,Capital Medical University,Beijing,China,100038)

机构地区：[1]首都医科大学附属北京世纪坛医院透析室,北京100038

出　　处：《分子诊断与治疗杂志》2023年第9期1496-1500,共5页Journal of Molecular Diagnostics and Therapy

基　　金：北京市自然科学基金面上项目(718251602)。

摘　　要：目的分析血液灌流联合序贯透析治疗对终末期肾脏疾病患者丙二醛(MDA)、尿素清除指数(KT/V)及血红蛋白(Hb)水平的影响。方法选取2021年10月至2022年10月期间首都医科大学附属北京世纪坛医院收治的终末期肾脏疾病患者121例为研究对象,按照治疗方法不同分为联合治疗组(血液灌流联合序贯透析治疗,n=62)和单一治疗组(序贯透析治疗,n=59)。对比两组一般资料,对比两组治疗前后氧化应激因子[MDA、晚期蛋白氧化产物(AOPPs)、超氧化物歧化酶(SOD)]、炎性因子[C反应蛋白(CRP)、肿瘤坏死因子⁃α(TNF⁃α)及白细胞介素⁃6(IL⁃6)]、营养指标[Hb、白蛋白(ALB)、总蛋白(TP)]水平以及治疗后KT/V水平。结果治疗前,两组一般情况比较,差异无统计学意义(P>0.05)。治疗后,两组MDA和晚期蛋白氧化产物(AOPPs)水平下降、超氧化物歧化酶(SOD)水平升高,且联合治疗组MDA、AOPPs水平低于单一治疗组、SOD水平高于单一治疗组,差异有统计学意义(P<0.05)。治疗后,两组C反应蛋白(CRP)、肿瘤坏死因子⁃α(TNF⁃α)、白细胞介素⁃6(IIL⁃6)水平均下降,且联合治疗组低于单一治疗组,差异有统计学意义(P<0.05)。治疗后,联合治疗组与单一组Hb、白蛋白(ALB)、总蛋白(TP)均升高,且联合治疗组水平高于单一治疗组,差异有统计学意义(P<0.05)。治疗后,联合治疗组KT/V达标人数占比高于单一治疗组,未达标人数低于单一治疗组,差异有统计学意义(P<0.05)。结论采用血液灌流联合序贯透析治疗能改善终末期肾脏疾病患者氧化应激因子、炎性因子及营养指标水平,提高KT/V达标率,具有临床应用价值,值得推广。Objective To analyze the effects of hemoperfusion combined with sequential dialysis treatment on malondialdehyde CAS(MDA),urea clearing index(KT/V)and hemoglobin(Hb)levels in patients with end⁃stage renal disease.Methods 121 patients with end⁃stage renal disease admitted to Beijing Millennium Temple Hospital Affiliated to Capital Medical University from October 2021 to October 2022 were selected as the research objects,and according to different treatment methods,they were divided into the combined treatment group(hemoperfusion combined with sequential dialysis treatment,n=62)and monotherapy group(sequential dialysis treatment,n=59).The general data between the two groups were compared,the oxidative stress factor[MDA,advanced protein oxidation products(AOPPs),superoxide dismutase(SOD)],inflammatory factors[C⁃reactive protein(CRP),tumor necrosis factor⁃α(TNF⁃α)and interleukin⁃6(IL⁃6)],and nutritional indexes[Hb,albumin(ALB),total protein(TP)]before and after treatment,and the KT/V level after treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference between the two groups in general conditions(P>0.05).After treatment,the levels of MDA and advanced oxidation protein products(AOPPs)decreased in the two groups,and the levels of superoxide dismutase(SOD)increased,and the levels of MDA and AOPPs in the combined treatment group were lower than those in the monotherapy group,and the SOD level in the combined treatment group was higher than that in the monotherapy group,the difference was statistically significant(P<0.05).After treatment,C⁃reactive protein(CRP),tumor necrosis factor⁃α(TNF⁃α),interleukin⁃6(IL⁃6)levels were decreased in the two groups,and the combined treatment group was lower than the single treatment group,the difference was statistically significant(P<0.05).After treatment,Hb,albumin(ALB),and total protein(TP)in the combined treatment group and the single treatment group all increased,and the levels in the combine

关 键 词：终末期肾脏疾病 血液灌流联合序贯透析治疗 MDA KT/V HB 

分 类 号：R446.1[医药卫生—诊断学] R692.5[医药卫生—临床医学]