血清Galectin⁃9、CXCL10对急性心肌梗死患者急诊PCI术后慢血流现象的预测效能  

Predictive effect of serum galectin⁃9 and CXCL10 on slow blood flow in patients with acute myocardial infarction after emergency PCI

作　　者：顾冬冬 程键 孔菲菲 吴海艳 刘玉飞 GU Dongdong;CHENG Jian;KONG Feifei;WU Haiyan;LIU Yufei(Department of Emergency Medicine,Hefei Jing Dong Hospital,Hefei,Anhui,China,231131)

机构地区：[1]合肥京东方医院急诊医学科,安徽合肥231131

出　　处：《分子诊断与治疗杂志》2023年第9期1515-1519,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省重点研究与开发计划项目(1704f0804023)。

摘　　要：目的探讨血清半乳糖凝集素⁃9(galectin⁃9)、血清CXC趋化因子配体10(CXCL10)对急性心肌梗死(AMI)患者急诊经皮冠状动脉介入治疗(PCI)术后冠状动脉慢血流(CSF)现象的评估价值。方法选取2019年12月至2022年12月合肥京东方医院收治的102例行急诊PCI术的AMI患者为研究组,另外选取同期来本院体检的100名健康体检者作为健康组。根据PCI术后连续校正TIMI帧数(CTFC)计数法将AMI患者分为CSF组(CTFC≥27帧)37例、血流正常组(CTFC<27帧)65例。采用酶联免疫吸附法检测血清Galectin⁃9、CXCL10水平,采用受试者工作特性(ROC)曲线评估血清Galectin⁃9、CXCL10对AMI患者急诊PCI术后CSF的预测价值,采用多因素Logistic回归分析探讨AMI患者急诊PCI术后CSF的影响因素。结果研究组血清Galectin⁃9、CXCL10水平均高于健康组(t=21.002,10.869,P<0.05)。CSF组血清Galectin⁃9、CXCL10水平高于血流正常组(t=10.929,11.133,P<0.05)。血清Galectin⁃9、CXCL10两者联合预测的AUC为0.901(0.864~0.938),优于单一检测(P<0.05)。CSF组高脂血症史比例、术中低血压比例、收缩压、舒张压、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL⁃C)、N末端脑钠肽前体(NTproBNP)、心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK⁃MB)、中性粒/淋巴细胞比率(NLR)、空腹血糖(FPG)及美国纽约心脏病协会(NYHA)分级Ⅲ~Ⅳ级占比高于血流正常组,LVEF低于血流正常组(P<0.05)。多因素Logistic回归分析显示,术中出现低血压、Galectin⁃9≥9.00μg/L、CXCL10≥9.82 ng/mL是AMI患者急诊PCI术后CSF的影响因素(P<0.05)。结论血清Galectin⁃9、CXCL10水平升高与AMI患者急诊PCI术后慢血流现象密切相关,可作为评估AMI患者急诊PCI术后慢血流现象的生物学指标,且两者联合预测的效能更高。Objective To explore the value of serum galectin⁃9(Galectin⁃9)and serum CXC chemokine ligand 10(CXCL10)in evaluating coronary slow flow(CSF)after emergency percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).Methods A total of 102 AMI patients who underwent emergency PCI in Hefei BOE Hospital from December 2019 to December 2022 were selected as the study group,and 100 healthy people who came to our hospital for physical examination during the same period were selected as the healthy group.AMI patients were divided into the CSF group(CTFC≥27 frames,n=37)and the normal flow group(CTFC<27 frames,n=65)according to continuous corrected TIMI frame count(CTFC)after PCI.Serum galectin⁃9 and CXCL10 levels were detected by enzyme⁃linked immunosorbent assay.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum galectin⁃9 and CXCL10 on CSF in AMI patients after emergency PCI.Multivariate Logistic regression analysis was used to explore the influencing factors of CSF in AMI patients after emergency PCI.Results The serum galectin⁃9 and CXCL10 levels in the study group were higher than those in the healthy group(t=10.929,11.133,P<0.05).The serum galectin⁃9 and CXCL10 levels in the CSF group were higher than those in the normal blood flow group(t=10.929,11.133,P<0.05).The combined prediction of serum galectin⁃9 and CXCL10 for the AUC was 0.901(0.864⁃0.938),which was superior to a single detection(P<0.05).The proportion of history of hyperlipidemia,proportion of intraoperative hypotension,systolic blood pressure,diastolic blood pressure,triacylglycerol(TG),low⁃density lipoprotein cholesterol(LDL⁃C),N⁃terminal pro⁃brain natriuretic peptide(NTproBNP),Cardiac troponin I(cTnI),creatine kinase isoenzyme(CK⁃MB),neutrophil/lymphocyte ratio(NLR),fasting blood glucose(FPG)and New York Heart Association(NYHA)classificationⅢ~Ⅳgrade proportion in the CSF group were higher than those in the normal blood flow group,and LVEF was lower

关 键 词：半乳糖凝集素⁃9 CXC趋化因子配体10 急性心肌梗死 冠状动脉慢血流 

分 类 号：R542.22[医药卫生—心血管疾病] R446.1[医药卫生—内科学]