RNA m6A修饰消化系统肿瘤研究进展  

Research advances of RNA N6-methyladenosine modification in digestive system tumors

作　　者：郭双铭 燕东 马晓春[1,3] 刘小军 Guo Shuangming;Yan Dong;Ma Xiaochun;Liu Xiaojun(The First Clinical Medical College,Chinese Medical University of Gansu,Lanzhou 730000,China;The Second Division of Anorectal Disease,Gansu Provincial Hospital,Lanzhou 730000,China;The Second Division of Radiation Oncology,Gansu Provincial Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]甘肃省人民医院肛肠科二病区,甘肃兰州730000 [3]甘肃省人民医院放疗科二病区,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2023年第8期90-94,共5页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金资助项目(21JR7RA618)。

摘　　要：N6-甲基腺嘌呤是真核细胞RNA常见的内部修饰。RNA的N6-甲基腺嘌呤修饰是可逆和动态的过程,依赖三大类调控蛋白(甲基转移酶、去甲基化酶和甲基化阅读蛋白)发挥作用。N6-甲基腺嘌呤调控蛋白与恶性肿瘤增殖、浸润及转移等过程关系密切,有望作为诊断、治疗和预后判断的潜在分子靶标。本研究总结了N6-甲基腺嘌呤修饰在常见消化道肿瘤的最新研究进展,并提出未来的研究方向与挑战。N6-methyladenosine is abundant inner RNA modifications in eukaryotes cells.The modification of N6-methyladenosine is reversible and dynamic and depends on three types of enzymes including methyltransferase,demethylase and readers.N6-methyladenosine RNA methylation regulating proteins play an important role in tumor proliferation,invasion and metastasis,and may be hopeful molecular targets for cancer diagnosis,treatment and prognosis.Here,we briefly reviewed the recent studies and future challenges of N6-methyladenosine methylation in common gastroenterological cancers.

关 键 词：N6-甲基腺嘌呤 消化道肿瘤 甲基转移酶 去甲基化酶 

分 类 号：R735.1[医药卫生—肿瘤]