广州市猴痘疫情流行病学特征分析  

Epidemiological characteristics of mpox epidemic in Guangzhou

作　　者：甄若楠 苏文哲[1] 温韵菁 骆诗韵 廖鑫龙 谭志勇 罗业飞 韩志刚 许建雄[1] 狄飚[1] 秦鹏哲[1] Zhen Ruonan;Su Wenzhe;Wen Yunjing;Luo Shiyun;Liao Xinlong;Tan Zhiyong;Luo Yefei;Han Zhigang;Xu Jianxiong;Di Biao;Qin Pengzhe(Guangzhou Center for Disease Control and Prevention,Guangzhou 510440,China)

机构地区：[1]广州市疾病预防控制中心,广州510440

出　　处：《中华流行病学杂志》2023年第9期1421-1425,共5页Chinese Journal of Epidemiology

基　　金：广州市医学重点学科(2021-2023-11);广州市卫生健康科技一般引导项目(20221A011072)。

摘　　要：目的了解广州市猴痘病例流行特征,为疫情防控工作提供科学依据。方法基于广州市猴痘监测网络体系,各级各类医疗卫生机构发现猴痘样症状者后报告疾控机构进行采样、处置,并落实明确诊断。广州市猴痘疫情流行特征采用描述性流行病学方法,对截至2023年6月23日24时广州市猴痘确诊病例基本信息、临床特征、就诊情况和阳性检出率等情况进行分析。使用Illumina Miniseq高通量测序平台进行病毒全基因组测序。结果6月10日,广州市报告广东省首例猴痘确诊病例。截至6月23日24时,广州市累计发现猴痘确诊病例25例,均为男性,年龄M(Q1,Q3)为32(26,36)岁,96.0%为MSM。病例发病至就诊时间间隔为1~12 d,M(Q1,Q3)为5(4,7)d。临床特征以皮疹(100.0%,25/25)、淋巴结肿大(100.0%,25/25)、发热(52.0%,13/25)为主,出疹部位多位于生殖器及其周边(88.0%,22/25)。密切接触者以家庭同住人员为主(40.4%,23/57),暂未出现发热、出疹等可疑症状。病例家庭环境样本阳性率为30.5%。3条猴痘病毒基因全序列分型均为西非型Ⅱb分支,B.1.3家系。结论猴痘病毒在广州市MSM中已发生隐匿性传播,但涉疫人群相对局限,社会面广泛传播可能性较低。Objective To understand the epidemiological characteristics of mpox epidemic in Guangzhou and provide scientific evidence for the prevention and control of the disease.Methods Based on the mpox surveillance system in Guangzhou,suspected mpox cases with fever and rash were reported by local hospitals at all levels to centers for disease control and prevention in Guangzhou for sampling,investigation and diagnosis.Descriptive epidemiological analysis was conducted on the clinical characteristics and treatment of the mpox cases and positive detection rate reported in Guangzhou as of 24:00 on June 23.Whole genome sequencing of the virus isolates was performed using Illumina Miniseq high-throughput sequencing platform.Results The first mpox case in Guangzhou was reported on June 10 in 2023.As of 24:00 on June 23,a total of 25 confirmed mpox cases were reported.All the mpox cases were men with a M(Q1,Q3)of 32(26,36)years,the majority of the cases were MSM(96.0%).The main clinical features were rash(100.0%,25/25),lymphadenectasis(100.0%,25/25)and fever(52.0%,13/25).Rash usually occurred near the genitals(88.0%,22/25).The close contacts,mainly family members(40.4%,23/57),showed no similar symptoms,such as fever or rash.The positive rate of mpox virus in household environment samples was 30.5%.The analyses on 3 complete gene sequences of mpox virus indicated that the strains belonged to West African typeⅡb clade,B.1.3 lineage.Conclusions Hidden transmission of mpox virus had occurred in MSM in Guangzhou.However,the size of affected population is relatively limited,and the possibility of wide spread of the virus is low.

关 键 词：猴痘 流行特征 

分 类 号：R511[医药卫生—内科学] R181.3[医药卫生—临床医学]