暴露对结局影响的非随机对照研究偏倚分析工具ROBINS-E(2022)的介绍  

Introduction of a tool to assess Risk of Bias in Non-randomized Studies-of Exposure(2022)

作　　者：孙悦皓 王晓晓[1,2] 裴敏玥[1,2] 马心洁 应又又 詹思延 李楠[1,2] Sun Yuehao;Wang Xiaoxiao;Pei Minyue;Ma Xinjie;Ying Youyou;Zhan Siyan;Li Nan(Research Center of Clinical Epidemiology,Peking University Third Hospital,Beijing 100191,China;Key Laboratory of Epidemiology of Major Diseases(Peking University),Ministry of Education,Beijing 100191,China;School of Nursing,Peking University,Beijing 100191,China;Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China)

机构地区：[1]北京大学第三医院临床流行病学研究中心,北京100191 [2]重大疾病流行病学教育部重点实验室(北京大学),北京100191 [3]北京大学护理学院,北京100191 [4]北京大学公共卫生学院流行病与卫生统计学系,北京100191

出　　处：《中华流行病学杂志》2023年第9期1454-1461,共8页Chinese Journal of Epidemiology

基　　金：国家自然科学基金(81701067)。

摘　　要：本文介绍了2022年6月最新版非随机对照研究偏倚分析工具ROBINS-E(2022)的内容并举例说明其使用方法。ROBINS-E是一种评估暴露相关非随机对照研究偏倚风险的工具。与ROBINS-E(2019)相比,ROBINS-E(2022)补充了更多适用于观察性研究的偏倚,涵盖的偏倚更加全面,同时增加了针对研究外部真实性的评估。ROBINS-E(2022)增加了初步评估环节,便于提高评估的效率。此外ROBINS-E(2022)使用路径图的形式将信号问题的使用进行了可视化和工具化,使用更加便捷。ROBINS-E(2022)虽然对共暴露的问题有了更多的考虑,但仍然没有解决共暴露中的效应修饰问题,仍有扩展适用的研究范围的空间。This article introduces the contents of the latest edition Risk of Bias in Non-randomized Studies-of Exposure(ROBINS-E)published in June 2022[ROBINS-E(2022)],and gives some examples about its usage.ROBINS-E is a tool for assessing the risk of bias in non-randomized studies-of exposure.Compared with ROBINS-E(2019),ROBINS-E(2022)adds more bias for observational studies,covers a more comprehensive range of bias,and adds the assessment of the external authenticity of the study.ROBINS-E(2022)adds a preliminary evaluation process to improve the efficiency of evaluation.In addition,ROBINS-E(2022)visualizes and instrumentalizes the use of signal problems in the form of path graph,making it more convenient to use.ROBINS-E(2022),although more consideration has been given to the issue of co-exposure,still does not address the problem of effect modification in co-exposure,and there is still room to expand the applicable research.

关 键 词：偏倚风险 评估工具 非随机对照研究 暴露 系统回顾 

分 类 号：R181[医药卫生—流行病学]