双膦酸盐的药学特点与临床应用  

Pharmaceutical characteristics and clinical application of bisphosphonates

作　　者：王欢 宋纯理[1] WANG Huan;SONG Chun-li(Department of Orthopaedics,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院骨科,北京100191

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2023年第3期281-289,共9页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家自然科学基金(82272554);国家重点研发计划课题(2020YFC2009004,2021YFC2501700)。

摘　　要：双膦酸盐药物的研发历程,是一部历经坎坷,充满神奇和些许运气的创新史,历经50年的研发,依旧是抗骨质疏松治疗的一线用药。科学家通过对双膦酸盐药物化学结构不断地修饰,其抗骨吸收的活性也不断增强,抗骨质疏松的疗效也逐渐提升,且广泛应用于肿瘤骨转移等疾病。本文综述双膦酸盐药物的发展史、化学结构、作用机制、药代动力学研究、临床应用及新剂型、不良反应及临床应用面临的问题,旨为双膦酸盐药物的临床应用提供参考。The history of bisphosphonates development is a history of hardships,full of magic,and a bit of luck.Bisphosphonates have become the first-line anti-osteoporosis treatment after 50 years of research and development.Its anti-bone resorption activity is enhanced by modifying the chemical structure of bisphosphonate.This paper reviewed the history of bisphosphonates,chemical structure,mechanism of action,pharmacokinetic,clinical application,new dosage forms,adverse reactions,and problems in clinical application,to provide a reference for the application of bisphosphonates.

关 键 词：双膦酸盐药物 破骨细胞 临床应用 骨质疏松 不良反应 

分 类 号：R681[医药卫生—骨科学]