Catalytic asymmetric synthesis of 1,4-enynes  

作　　者：Han-Yu Lu Zhi-Tao He 

机构地区：[1]CAS Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Shanghai 200032,China [2]School of Physical Science and Technology,ShanghaiTech University,Shanghai 201210,China [3]School of Chemistry and Materials Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China

出　　处：《Chinese Chemical Letters》2023年第8期18-27,共10页中国化学快报（英文版）

基　　金：We are grateful for the financial support from the National Natural Science Foundation of China(NSFC,No.22071262);the Science and Technology Commission of Shanghai Municipality(No.22ZR1475200);Shanghai Rising-Star program(No.20QA1411300).

摘　　要：1,4-Enyne units are ubiquitous skeletons in biologically active molecules and natural products.Especially,they represent versatile building blocks for abundant downstream derivatizations via controllable modifications of both alkene and alkyne units independently.Recently,great efforts have been made to establish efficient protocols to achieve optically active 1,4-enynes.Considering the enormous application potential of enantioenriched 1,4-enyne units but no related review on this topic has been described,here we aim to provide a comprehensive summary on the catalytic methods established for enantioselective constructions of these intriguing skeletons.According to the reaction types,this review is divided into five parts,including asymmetric allylic substitution,asymmetric propargylic substitution,asymmetric alkynylallylic substitution,asymmetric hydroalkynylation and asymmetric 1,2-addition of alkynes to conjugated imines or ketones.

关 键 词：1 4-Enynes Catalytic reaction Asymmetric synthesis 

分 类 号：O621.251[理学—有机化学] O623.12[理学—化学]