酸枣仁水提取物中的三萜类成分  

Triterpenoids from an aqueous extract of the Ziziphus jujuba var.spinosa seeds

作　　者：郝文飒 朱承根 雷小强 徐成博 郭庆兰 石建功 HAO Wen-sa;ZHU Cheng-gen;LEI Xiao-qiang;XU Cheng-bo;GUO Qing-lan;SHI Jian-gong(Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院、北京协和医学院药物研究所,天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《药学学报》2023年第9期2734-2745,共12页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目[82293681,82293685(82293680)];中国医学科学院医学与健康科技创新工程项目(2022-I2M-JB-011,2021-I2M-1-028)。

摘　　要：通过大孔吸附树脂、MCI树脂、正相硅胶、Sephadex LH-20和Toyopearl HW-40C柱色谱结合制备薄层色谱和反相HPLC等多种色谱分离方法,从酸枣仁水提取物中分离得到4个新三萜苷类及6个已知三萜类化合物。利用多种波谱学方法,结合酸水解反应,确定了它们的结构,新化合物分别命名为酸枣仁美洲茶酸苷A(1)、23-表酸枣仁皂苷A(2)及酸枣仁皂苷J和K(3和4),已知化合物鉴定为酸枣仁皂苷A~C(5~7)、酸枣仁皂苷II(8)、卖珠子酸(9)和白桦脂酸(10)。其中,1的结构得到单晶X-射线衍射分析的确证。Four new triterpenoids,together with six known analogues,were isolated from an aqueous extract of the Ziziphus jujuba var.spinosa seeds,by multiple column chromatographic separation methods using stationary phases of macroporous adsorption resin,MCI resin,normal phase silica gel,Sephadex LH-20,and Toyopearl HW-40C as well as preparative thin-layer chromatography and reversed-phase HPLC.Their structures were determined by spectroscopic data analysis,the new structures were trivially named jujubaceanothoside A(1),23-epijujuboside A(2),and jujubosides J and K(3 and 4),while the known analogues were identified as jujubosides A-C(5-7)and II(8),alphitolic acid(9),and betulinic acid(10).The structure of 1 was confirmed by single crystal X-ray diffraction.

关 键 词：鼠李科 枣属 酸枣 三萜 酸枣仁美洲茶酸苷A 酸枣仁皂苷衍生物 

分 类 号：R284[医药卫生—中药学]