Glucose uptake and distribution across the human skeleton using state-of-the-art total-body PET/CT  

作　　者：Weizhao Lu Yanhua Duan Kun Li Jianfeng Qiu Zhaoping Cheng 

机构地区：[1]Department of Radiology,Shandong First Medical University&Shandong Academy of Medical Sciences,Taian 271016,China [2]Department of PET-CT,the First Affiliated Hospital of Shandong First Medical University,Shandong Provincial Qianfoshan Hospital Affiliated with Shandong University,Jinan 250014,China

出　　处：《Bone Research》2023年第3期586-594,共9页骨研究（英文版）

基　　金：supported by the Science and Technology Funding from Jinan (grant number:2020GXRC018);the Academic Promotion Program of Shandong First Medical University (grant number:2019QL009);the Taishan Scholars Program of Shandong Province (grant number:TS201712065)。

摘　　要：A growing number of studies have demonstrated that the skeleton is an endocrine organ that is involved in glucose metabolism and plays a significant role in human glucose homeostasis.However,there is still a limited understanding of the in vivo glucose uptake and distribution across the human skeleton.To address this issue,we aimed to elucidate the detailed profile of glucose uptake across the skeleton using a total-body positron emission tomography(PET)scanner.A total of 41 healthy participants were recruited.Two of them received a 1-hour dynamic total-body^(18)F-fluorodeoxyglucose(^(18)F-FDG)PET scan,and all of them received a10-minute static total-body^(18)F-FDG PET scan.The net influx rate(K_i)and standardized uptake value normalized by lean body mass(SUL)were calculated as indicators of glucose uptake from the dynamic and static PET data,respectively.The results showed that the vertebrae,hip bone and skull had relatively high Kiand SUL values compared with metabolic organs such as the liver.Both the K_(i) and SUL were higher in the epiphyseal,metaphyseal and cortical regions of long bones.Moreover,trends associated with age and overweight with glucose uptake(SUL_(max)and SUL_(mean))in bones were uncovered.Overall,these results indicate that the skeleton is a site with significant glucose uptake,and skeletal glucose uptake can be affected by age and dysregulated metabolism.

关 键 词：METABOLISM SKELETON ORGANS 

分 类 号：R68[医药卫生—骨科学] R817.4[医药卫生—外科学]