晚期糖基化终末产物对心血管系统的影响研究现状  

Impact of advanced glycation end products on cardiovascular system:a review

作　　者：程瑞洁 刘烈刚 陈梁凯 CHENG Rui-jie;LIU Lie-gang;CHENG Liang-kai(Department of Nutrition and Food Hygiene,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Hubei Key Laboratory of Food Nutrition and Safety,Wuhan,Hubei 430030,China;不详)

机构地区：[1]华中科技大学公共卫生学院营养与食品卫生学系湖北省食品营养与安全重点实验室,湖北武汉430030 [2]华中科技大学同济医学院公共卫生学院环境与健康教育部重点实验室

出　　处：《江苏预防医学》2023年第4期433-436,共4页Jiangsu Journal of Preventive Medicine

基　　金：国家自然基金重点项目:长期高脂饮食对AD病变的影响及机制研究(81230069)。

摘　　要：人体血浆中高水平晚期糖基化终末产物(advanced glycation end⁃products,AGEs)是糖尿病的重要病因和病理表现,并可引起一系列心血管疾病。AGEs在心血管疾病发病中的作用受到广泛关注,相关研究已较为深入,主要通过与受体结合激活细胞内信号通路,或与大分子结合改变构象及功能,从而引起心血管疾病的发生、发展。现对AGEs对心血管疾病的作用及两者剂量效应关系的流行病学和基础研究进行综述,为进一步研究提供参考。High plasma levels of advanced glycation end products(AGEs)are a major cause and pathological manifestation of di⁃abetes,and may induce multiple cardiovascular diseases.The contribution of AGEs to the pathogenesis of cardiovascular diseases has re⁃ceived wide attention,and the underlying mechanisms have been extensively investigated.AGEs bind to receptors to activate intracellular signaling pathways,or bind to macromolecules to alter configuration and functions,thereby resulting in the development and progression of cardiovascular diseases.This article reviews the epidemiological and basic studies on the effect of AGEs on cardiovascular diseases and the dose⁃effect relationship between AGEs and cardiovascular diseases,so as to provide insights into further studies.

关 键 词：晚期糖基化终末产物 心血管系统 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]