The Link between Exposure to Phthalates and Type 2 Diabetes Mellitus:A Study Based on NHANES Data and Bioinformatic Analysis  

作　　者：LIU Xue Kui SI Shan Wen YE Yan LI Jia Yi LYU He He MA Ya Mei ZOU Cai Yan SUN Hao Jie XUE Lei XU Wei GENG Hou Fa LIANG Jun 

机构地区：[1]Department of Endocrinology,Xuzhou Central hospital,Xuzhou 221009,Jiangsu,China [2]Xuzhou Medical University,Affiliated Xuzhou Clinical College of Xuzhou Medical University,Xuzhou 221009,Jiangsu,China [3]Graduate School of Bengbu Medical College,Bengbu 233000,Anhui,China [4]Department of Emergency,Xuzhou Central Hospital,Xuzhou 221009,Jiangsu,China

出　　处：《Biomedical and Environmental Sciences》2023年第9期892-896,共5页生物医学与环境科学（英文版）

基　　金：supported by generous grants from the Natural Science Foundation of Jiangsu Province [BK20171171];Social Development Project of the Xuzhou Municipal Science and Technology Bureau [KC21208,KC21231];China International Medical Foundation [2021-N-03];Foundation of Affiliated Hospital of Xuzhou Medical University [XYFZ2020007]。

摘　　要：Insulin resistance is closely associated with metabolic disorders and the pathogenesis of type 2 diabetes mellitus(T2DM).Accumulating evidence suggests that excess fatty acids due to inappropriate lipolysis increase the risk of insulin resistance,which,in turn,stimulates hyperinsulinemia,worsens metabolism,and leads to insulin resistance due to impairedβ-cell function.

关 键 词：METABOLISM IMPAIRED function. 

分 类 号：R587.1[医药卫生—内分泌]