基于R语言探讨古代中医文献中治疗骨质疏松症的中药用药规律  

Exploring the Medication Rules of Chinese Herbal Medicine for Osteoporosis in Ancient Chinese Medical Literature Based on R Language

作　　者：胡容瑞 曾智君 关宏刚[3] 梁晓静 HU Rong-Rui;ZENG Zhi-Jun;GUAN Hong-Gang;LIANG Xiao-Jing(The Eighth Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510800 Guangdong,China;Clinical Medical School of Acupuncture,Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;Foshan Hospital of Traditional Chinese Medicine,Foshan 528000 Guangdong,China;Guangdong Huangpu Health Vocational and Technical School,Guangzhou 510006 Guangdong,China)

机构地区：[1]广州中医药大学第八临床医学院,广东佛山528000 [2]广州中医药大学针灸康复临床医学院,广东广州510006 [3]佛山市中医院,广东佛山528000 [4]广东黄埔卫生职业技术学校,广东广州510006

出　　处：《广州中医药大学学报》2023年第9期2375-2380,共6页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】挖掘分析古代中医文献中采用中药治疗骨质疏松症的用药规律,为临床运用中药治疗骨质疏松症提供参考。【方法】以“骨痿”“骨枯”“肾痿”为关键词,计算机检索第5版《中华医典》中采用内服中药治疗骨质疏松症的方剂。采用Excel软件对方药信息进行提取,采用R语言对中药进行使用频次分析、关联规则分析及聚类分析。【结果】共筛选得到治疗骨质疏松症的方剂88首,中药183味,总频次为902次;高频中药(使用频次≥10次)有25味,使用频次居于前5位的依次为牛膝、熟地黄、菟丝子、肉苁蓉、杜仲。高频药物根据其功效进行分类,主要可分为补虚药、利水渗湿药、收涩药、清热药、温里药、祛风湿药。关联规则分析得到281条关联规则,其中关联度最高的前5个药对为熟地黄-牛膝、菟丝子-肉苁蓉、菟丝子-牛膝、肉苁蓉-牛膝、杜仲-牛膝。关联规则分析和聚类分析形成以牛膝、熟地黄、菟丝子、肉苁蓉、杜仲为基础的核心药物组合。【结论】古代医家采用中药治疗骨质疏松症以补肾为基本原则,酌情加入针对湿浊、血瘀、脾虚等病机的中药。挖掘得到的核心药物组合可为骨质疏松症的临床治疗提供一定的参考。Objective To explore the medication rules of Chinese medicine in ancient Chinese medical literature for the treatment of osteoporosis by data mining methods,and to provide reference for the clinical use of Chinese medicine in the treatment of osteoporosis.Methods Using“flaccidity of bones”,“bone necrosis”and“kidney Shudihuang-Niuxi,Tusizi-Roucongrong,Tusizi-Niuxi,Roucongrong-Niuxi,and Duzhong-Niuxi.The results of association rule analysis and cluster analysis yield the core drug combinations of Niuxi,Shudihuang,Tusizi,Roucongrong,and Duzhong.Conclusion For the treatment of osteoporosis,ancient medical practitioners follow the basic therapeutic principle of tonifying the kidney,make the modified use of herbs targeted the pathogenesis of turbid dampness,blood stasis and spleen deficiency if necessary.The core drug combinations obtained from the data mining can provide some reference for the clinical treatment of osteoporosis.

关 键 词：骨质疏松症 《中华医典》 补肾 牛膝 熟地黄 菟丝子 肉苁蓉 杜仲 R语言 

分 类 号：R274.9[医药卫生—中西医结合]