特发性早发性卵巢功能不全患者中医体质分析  

Analysis of Traditional Chinese Medicine Constitution in Patients with Idiopathic Premature Ovarian Insufficiency

作　　者：林雨乔 刘建[2] 杨洪艳[2] LIN Yu-Qiao;LIU Jian;YANG Hong-Yan(The Second Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120 Guangdong,China)

机构地区：[1]广州中医药大学第二临床医学院,广东广州510006 [2]广东省中医院,广东广州510120

出　　处：《广州中医药大学学报》2023年第10期2431-2437,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81874481);广东省中医院临床研究专项(编号:1010专项)。

摘　　要：【目的】研究特发性早发性卵巢功能不全(premature ovarian insufficiency,POI)患者的中医体质特点。【方法】采用病例对照研究方法,将2016年10月至2018年10月就诊于广东省中医院妇科门诊的150例特发性POI患者作为病例组,另将同期在本院体检的145例年龄匹配、月经正常的非POI女性健康人群作为对照组,比较2组的中医体质分布差异,分析特发性POI患者的中医体质分布特点。【结果】(1)与对照组的体质转化分相比,病例组的平和质得分较低,气虚质、湿热质得分较高,差异有统计学意义(P<0.05或P<0.01)。(2)病例组的偏颇质共119例(79.3%),对照组共100例(69.0%),病例组的偏颇质较对照组多,差异有统计学意义(P<0.05)。其中,病例组出现频次较高的偏颇质有气虚质74例(49.3%)、阳虚质70例(46.7%)、血瘀质56例(37.3%),对照组出现频次较高的偏颇质有阳虚质51例(35.2%)、血瘀质50例(34.5%)。与对照组相比,病例组出现气虚质、阳虚质的频次较多,差异有统计学意义(P<0.05)。(3)病例组中兼夹体质患者占75.6%(90/119),对照组占72.0%(72/100);POI气虚质患者易兼夹气郁质、血瘀质、痰湿质、湿热质,POI阳虚质患者易兼夹气虚质。(4)POI气虚质患者的症状以疲乏为主,阳虚质患者的症状以怕冷为主。【结论】特发性POI患者与非POI女性健康人群的中医体质分布存在差异,体质兼夹现象普遍存在;POI患者的中医体质多为偏颇质,以气虚质、阳虚质为主,气虚质患者易兼夹气郁质、血瘀质、痰湿质、湿热质,阳虚质患者易兼夹气虚质。Objective To study the characteristics of traditional Chinese medicine(TCM)constitution in patients with idiopathic premature ovarian insufficiency(POI).Methods A case-control study was conducted.A total of150 idiopathic POI patients who attended the Gynecology Outpatient Clinic of Guangdong Provincial Hospital of Chinese Medicine from October 2016 to October 2018 served as the case group,and 145 age-matched non-POI female population with normal menstruation who had physical examination in our hospital during the same period were included as the control group.The differences in the distribution of TCM constitution between the two groups were compared for revealing the characteristics of TCM constitution in patients with idiopathic POI.Results(1)Compared with the control group,the case group had lower scores of balanced constitution and higher scores of qi deficiency constitution and damp-heat constitution,and the difference was statistically significant(P<0.05 or P<0.01).(2)There were 119 cases(79.3%)of biased constitution in the case group and 100 cases(69.0%)in the control group,the case group had more cases of biased constitution than the control group,and the difference was statistically significant(P<0.05).In the case group,the high-frequency biased constitution types were qi deficiency constitution[74 cases(49.3%)],yang deficiency constitution[70 cases(46.7%)]and blood stasis constitution[56 cases(37.3%)];in the control group,the high-frequency biased constitution types were yang deficiency constitution[51 cases(35.2%)]and blood stasis constitution[50 cases(34.5%)].Compared with the control group,the case group had a higher frequency of qi deficiency constitution and yang deficiency constitution,and the difference was statistically significant(P<0.05).(3)Patients with concurrent constitution in the case group accounted for 75.6%(90/119)and those in the control group accounted for 72.0%(72/100).Idiopathic POI patients with qi deficiency constitution were prone to concurrently have qi depression constitution,

关 键 词：特发性早发性卵巢功能不全 中医体质 气虚质 阳虚质 

分 类 号：R271.9[医药卫生—中西医结合]