红鹿合剂联合托特罗定治疗湿热下注型间质性膀胱炎的临床研究  

Clinical Study on the Honglu Mixture Combined with Tolterodine in the Treatment of Interstitial Cystitis of Damp-Heat Downward Attacking Type

作　　者：吴效通 冯懿赓 陈磊[1] 曹宏文[1] 赵文洋 李海滨 宋子希 WU Xiao-Tong;FENG Yi-Geng;CHEN Lei;CAO Hong-Wen;ZHAO Wen-Yang;LI Hai-Bin;SONG Zi-Xi(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《广州中医药大学学报》2023年第10期2491-2496,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:82174199)。

摘　　要：【目的】观察具有清热利湿作用的红鹿合剂(由红藤、鹿衔草、黄柏、白花蛇舌草、红花、当归等中药组成)联合托特罗定治疗湿热下注型间质性膀胱炎的临床疗效。【方法】将123例湿热下注型间质性膀胱炎患者随机分为2组,其中试验组61例,对照组62例。对照组给予口服托特罗定治疗,试验组在对照组的基础上联合红鹿合剂治疗,疗程为12周。观察2组患者治疗前后间质性膀胱炎症状指数(ICSI)评分、盆腔疼痛和尿频尿急症状调查表(PUF)评分、焦虑自评量表(SAS)评分和中医证候积分(包括尿频、尿急、尿痛、排尿灼热等)的变化情况,并评价2组患者的临床疗效和安全性。【结果】(1)脱落情况:研究过程中,共失访、脱落9例(其中试验组4例,对照组5例),最终纳入114例,其中试验组和对照组各有57例。(2)疗效情况:治疗12周后,试验组的总有效率为78.95%(45/57),对照组为63.16%(36/57);组间比较,试验组的临床疗效明显优于对照组(P<0.05)。(3)量表评分情况:治疗后,2组患者的ICSI评分、PUF评分、SAS评分和中医证候积分均较治疗前下降(P<0.05或P<0.01),且试验组对ICSI评分、PUF评分和中医证候积分的下降作用均明显优于对照组(P<0.05)。(4)不良反应情况:治疗过程中,2组患者均未发生明显不良反应,各项安全性指标均无异常变化,具有较高的安全性。【结论】红鹿合剂联合托特罗定能够有效治疗湿热下注型间质性膀胱炎患者的尿频、尿急、尿痛等症状,缓解患者的心理焦虑,改善患者的生活质量。Objective To observe the clinical efficacy of Honglu Mixture(composed of Sargentodoxae Caulis,Pyrolae Herba,Phellodendri Chinensis Cortex,Hedyotis Diffusae Herba,Carthami Flos,Angelicae Sinensis Radix,etc.),which has the effect of clearing heat and draining dampness,combined with Tolterodine in the treatment of interstitial cystitis of damp-heat downward attacking type.Methods A total of 123 patients with interstitial cystitis of damp-heat downward attacking type were randomly divided into 2 groups,i.e.,61 cases in the trial group and 62 cases in the control group.The control group was given oral use of Tolterodine,and the trial group was treated with Honglu Mixture orally on the basis of treatment for the control group.Both groups were treated for 12 weeks.The changes in the Interstitial Cystitis Symptom Index(ICSI)scores,Pelvic Pain and Urgency-Frequency Symptom System(PUF)scores,Self-Rating Anxiety Scale(SAS)scores and traditional Chinese medicine(TCM)syndrome score(including frequent micturition,urgent micturition,painful urination and burning sensation in micturition)in the two groups were observed before and after treatment,and the clinical efficacy and safety of the patients in the two groups were evaluated.Results(1)During the trial,9 cases were lost and fell off(4 cases from the trial group and 5 cases from the control group),and 114 cases were finally included,including 57 cases in the trial group and 57 cases in the control group.(2)After 12 weeks of treatment,the overall effective rate in the trial group was 78.95%(45/57)and that in the control group was 63.16%(36/57).The intergroup comparison showed that the clinical efficacy of the trial group was significantly superior to that of the control group(P<0.05).(3)Afer treatment,the ICSI scores,PUF scores,SAS scores and TCM syndrome scores of the two groups were decreased compared with those before treatment(P<0.05 or P<0.01),and the decrease of ICSI scores,PUF scores and TCM syndrome scores in the trial group was significantly superior to that in the co

关 键 词：红鹿合剂 托特罗定 间质性膀胱炎 湿热下注 清热利湿 临床疗效 安全性 

分 类 号：R277.5[医药卫生—中医学]