心脏脱细胞基质水凝胶制备及其对心肌梗死修复的研究进展  

Preparation of Cardiac Decellularized Extracellular Matrix Hydrogel and Its Application in Myocardial Infarction Repair

作　　者：张雅楠 许锋 ZHANG Yanan;XU Feng(Guangxi Medical University,Collaborative Innovation Center of Regenerative Medicine and Medical Biological Resources Development and Application,Guangxi Key Laboratory of Regenerative Medicine,Nanning 530021 Guangxi,China;Shanghai Jiao Tong University,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]广西医科大学,再生医学与医用生物资源开发应用协同创新中心,广西再生医学重点实验室,广西南宁530021 [2]上海交通大学上海交通大学医学院附属第九人民医院,上海200011

出　　处：《心血管病学进展》2023年第9期823-827,共5页Advances in Cardiovascular Diseases

摘　　要：心肌组织通过物理、化学或其他方法进行脱细胞处理后,制备成的脱细胞基质含有许多细胞外基质成分,包括蛋白质、胶原、多糖以及生长因子等,不仅对细胞生长有很好的生物相容性,而且还能有助于细胞的修复和再生,是一种很有前途的心血管修复材料。脱细胞基质水凝胶是将脱细胞基质进行凝胶化后,所形成的一种具有生物相容性、可降解性以及可注射性的生物材料,不仅保留了脱细胞基质本身的优点,而且增加了可注射性这一优势,可在心肌梗死后进行微创注射,从而对心脏产生修复作用。After decellularization of myocardial tissue by physical,chemical or other methods,the prepared decellularized extracellular matrix(dECM) contains many extracellular matrix components,including proteins,collagen,polysaccharides and growth factors.It not only has good biocompatibility for cell growth,but also contributes to cell repair and regeneration,which is a promising material for cardiovascular repair.dECM hydrogel is a biocompatible,degradable and injectable biological material formed after gelling the dECM,which not only retains the advantages of the dECM itself but also increases the advantage of injectability,and can be minimally invasive injection after myocardial infarction,thereby having a repair effect on the heart.

关 键 词：脱细胞基质 可注射水凝胶 心肌梗死 心脏修复 再生医学 

分 类 号：R318.08[医药卫生—生物医学工程] R542.22[医药卫生—基础医学]