孕妇及脐带静脉血中VitB_(12)、叶酸和HCY含量与胎儿生长受限的相关性研究  

Relationship of the contents of VitB_(12),folic acid,and HCY in pregnant women and umbilical cord venous blood with fetal growth restriction

作　　者：高颖[1] 杨俊娟[1] 柳蕊 GAOYing;YANG Jun-juan;LIU Rui(Department of Obstetrics,Zhengzhou Maternity and Child Health Hospital,Zhengzhou 450000,Henan,CHINA)

机构地区：[1]郑州市妇幼保健院产科,河南郑州450000

出　　处：《海南医学》2023年第17期2540-2543,共4页Hainan Medical Journal

基　　金：2020年河南省医学科技攻关计划联合共建项目(编号:LHGJ20200748)。

摘　　要：目的探讨孕妇及脐带静脉血中VitB_(12)、叶酸及同型半胱氨酸(HCY)的含量与胎儿生长受限(FGR)的相关性。方法选取2019年1月1日至2022年12月31日在郑州市妇幼保健院产科分娩的84例FGR患儿作为FGR组,另选择同期在我院分娩的84例正常新生儿作为对照组。比较两组新生儿生长指标、孕妇及脐带静脉血中VitB_(12)、叶酸及HCY含量,采用Pearson相关性检验分析孕妇及脐带静脉血血清VitB_(12)、叶酸及HCY含量与新生儿生长指标的相关性。结果FGR组出生体质量、出生身长、出生头围分分别为(2.18±0.46)kg、(45.89±1.14)cm、(27.65±0.87)cm,均明显低于对照组的(3.42±0.51)kg、(50.37±1.59)cm、(33.06±0.96)cm,差异均有统计学意义(P<0.05);FGR组孕妇静脉血血清VitB_(12)、叶酸的含量分别为(54.28±11.69)ng/L、(3.69±1.43)μg/L,脐带静脉血分别为(45.32±10.71)ng/L、(5.22±1.65)μg/L,均明显低于对照组孕妇静脉血的(417.24±57.25)ng/L、(16.77±3.74)μg/L和脐带静脉血的(278.38±58.35)ng/L、(18.35±3.80)μg/L,差异均有统计学意义(P<0.05);FGR组孕妇静脉血中血清HCY含量为(47.98±7.99)μmol/L,脐带静脉血中血清HCY含量为(28.29±4.87)μmol/L,均高于对照组孕妇静脉血的(8.58±2.51)μmol/L和脐带静脉血的(8.95±2.55)μmol/L,差异均有统计学意义(P<0.05);经Pearson相关性检验分析结果显示,孕妇静脉血中血清VitB_(12)、叶酸、HCY含量与脐带静脉血中的含量呈正相关(P<0.05);孕妇及脐带静脉血中血清VitB_(12)、叶酸含量与新生儿出生体质量、出生身长和出生头围呈正相关(P<0.05),而孕妇及脐带静脉血HCY含量与新生儿出生体质量、出生身长和出生头围呈负相关(P<0.05)。结论孕妇及脐带静脉血低VitB_(12)、叶酸含量及高HCY含量可能引起FGR发生,临床可根据孕妇静脉血血清VitB_(12)、叶酸及HCY含量推测胎儿是否缺乏VitB_(12)、叶酸,以及HCY含量是否过高,并及时采取干预措施,减少FGR�Objective To explore the correlation of the contents of VitB_(12),folate acid,homocysteine(HCY)in pregnant women and umbilical cord venous blood with fetal growth restriction(FGR).Methods Eighty-four newborns with FGR born in Zhengzhou Maternity and Child Health Hospital from January 1,2019 to December 31,2022 were selected as the FGR group,and 84 normal newborns born in the hospital at the same period were selected as the control group.The neonatal growth indicators,the contents of VitB_(12),folic acid,and HCY in pregnant women and umbilical cord venous blood were compared between the two groups.The correlation of the contents of VitB_(12),folic acid,and HCY in pregnant women and umbilical cord venous blood with neonatal growth indicators was analyzed by Pearson correlation test.Results The birth weight,birth length,and birth head circumference of the FGR group were(2.18±0.46)kg,(45.89±1.14)cm,and(27.65±0.87)cm,respectively,which were significantly lower than(3.42±0.51)kg,(50.37±1.59)cm,and(33.06±0.96)cm of the control group(P<0.05).The contents of VitB_(12),folic acid were(54.28±11.69)ng/L,(3.69±1.43)μg/L in venous blood of pregnant women and(45.32±10.71)ng/L,(5.22±1.65)μg/L in umbilical cord venous blood in FGR group,which were significantly lower than(417.24±57.25)ng/L,(16.77±3.74)μg/L in venous blood of pregnant women and(278.38±58.35)ng/L,(18.35±3.80)μg/L in umbilical cord venous blood in the control group(P<0.05).The content of HCY was(47.98±7.99)μmol/L in venous blood of pregnant women and(28.29±4.87)μmol/L in umbilical cord venous blood in the FGR group,which was significantly higher than(8.58±2.51)μmol/L and(8.95±2.55)μmol/L in the control group(P<0.05).Pearson correlation results showed that the contents of serum VitB_(12),folic acid,and HCY in venous blood of pregnant women were positively correlated with those in umbilical cord venous blood(P<0.05);the serum VitB_(12) and folic acid content of pregnant women and umbilical cord venous blood were positively correlated with the

关 键 词：胎儿生长受限 维生素B_(12) 叶酸 同型半胱氨酸 相关性 

分 类 号：R714.12[医药卫生—妇产科学]