25-(OH)-D、钙及Hcy水平与妊娠期高血压患者妊娠结局的关系研究  

Relationship between the levels of 25-(OH)-D,calcium and Hcy with pregnancy outcome in patients with gestational hypertension

作　　者：解娟[1] 李博[1] 张思若 XIE Juan;LI Bo;ZHANG Siruo(Department of Clinical Laboratory,Shaanxi Provincial People's Hospital,Xi'an,Shaanxi 710068,China)

机构地区：[1]陕西省人民医院检验科,陕西西安710068

出　　处：《检验医学与临床》2023年第19期2790-2793,共4页Laboratory Medicine and Clinic

基　　金：中华国际科学交流基金会项目(Z2022LSXB014)。

摘　　要：目的探讨25-羟维生素D[25-(OH)-D]、钙及同型半胱氨酸(Hcy)水平与妊娠期高血压患者妊娠结局的关系。方法回顾性分析该院2021年1月至2023年1月收治的84例妊娠期高血压患者的临床资料,根据妊娠结局分为不良妊娠结局组(44例)和良好妊娠结局组(40例)。比较两组临床资料,检测血清25-(OH)-D、钙及Hcy水平;通过受试者工作特征(ROC)曲线分析25-(OH)-D、钙、Hcy水平预测妊娠期高血压患者不良妊娠结局的价值;采用多因素Logistic回归分析妊娠期高血压患者不良妊娠结局的危险因素。结果不良妊娠结局组25-(OH)-D、钙水平显著低于良好妊娠结局组(P<0.05),Hcy水平显著高于良好妊娠结局组(P<0.05);ROC曲线分析结果显示,25-(OH)-D、钙、Hcy水平预测妊娠期高血压患者不良妊娠结局的曲线下面积分别为0.743、0.770、0.862;多因素Logistic回归分析发现,25-(OH)-D、钙水平降低,以及Hcy水平升高是妊娠期高血压患者不良妊娠结局的危险因素(P<0.05)。结论25-(OH)-D、钙及Hcy水平与妊娠期高血压患者的妊娠结局有关,低25-(OH)-D、钙水平及高Hcy水平可预测不良妊娠结局。Objective To explore the relationship between the levels of 25-hydroxyvitamin D[25-(OH)-D],calcium and homocysteine(Hcy)with the pregnancy outcome in the patients with pregnancy-induced hypertension.Methods The clinical data of 84 patients with pregnancy-induced hypertension admitted and treated in this hospital from January 2021 to January 2023 were analyzed retrospectively.The patients were divided into the poor pregnancy outcome group(44 cases)and good pregnancy outcome group(40 cases)according to the pregnancy outcome.The clinical data were compared between the two groups and the levels of serum 25-(OH)-D,calcium and Hcy were detected.The value of 25-(OH)-D,calcium and Hcy levels in predicting the adverse pregnancy outcomes in the patients with pregnancy-induced hypertension was analyzed by the receiver operating characteristic(ROC)curve.The risk factors of poor pregnancy outcomes in the patients with pregnancy-induced hypertension were analyzed by adopting the multivariate Logistic regression analysis.Results The levels of 25-(OH)-D and calcium in the poor pregnancy outcome group were significantly lower than those in the good pregnancy outcome group,and the level of Hcy was significantly higher than that in the good pregnancy outcome group(P<0.05).The ROC curve analysis results showed that the areas under the curve of 25-(OH)D,calcium and Hcy levels for predicting the poor pregnancy outcomes in the patients with pregnancy-induced hypertension were 0.743,0.770 and 0.862 respectively.The multivariate Logistic regression analysis showed that the decrease in 25-(OH)-D and calcium levels and the increase in Hcy level were the risk factors for the poor pregnancy outcome in the patients with pregnancy-induced hypertension(P<0.05).Conclusion The levels of 25-(OH)-D,calcium and Hcy are related with the pregnancy outcomes in the patients with pregnancy-induced hypertension.Low 25-(OH)-D level,low calcium level and high Hcy level could predict the poor pregnancy outcome.

关 键 词：25-羟维生素D 钙 同型半胱氨酸 妊娠期高血压 妊娠结局 

分 类 号：R714.25[医药卫生—妇产科学]